Cargando…

Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain

The genus Circovirus includes several species and mostly causes asymptomatic infections. Porcine circovirus 2 (PCV-2) and, with increasing evidence, Porcine circovirus 3 (PCV-3), have been associated with different clinical conditions all over the world. In 2019, a new porcine circovirus (PCV-4) was...

Descripción completa

Detalles Bibliográficos
Autores principales: Franzo, Giovanni, Ruiz, Albert, Grassi, Laura, Sibila, Marina, Drigo, Michele, Segalés, Joaquim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350368/
https://www.ncbi.nlm.nih.gov/pubmed/32486429
http://dx.doi.org/10.3390/pathogens9060433
_version_ 1783557253566038016
author Franzo, Giovanni
Ruiz, Albert
Grassi, Laura
Sibila, Marina
Drigo, Michele
Segalés, Joaquim
author_facet Franzo, Giovanni
Ruiz, Albert
Grassi, Laura
Sibila, Marina
Drigo, Michele
Segalés, Joaquim
author_sort Franzo, Giovanni
collection PubMed
description The genus Circovirus includes several species and mostly causes asymptomatic infections. Porcine circovirus 2 (PCV-2) and, with increasing evidence, Porcine circovirus 3 (PCV-3), have been associated with different clinical conditions all over the world. In 2019, a new porcine circovirus (PCV-4) was identified from diseased animals in China. Because of the lessons learned from PCV-2 and PCV-3, it appears mandatory to investigate the actual distribution of this new virus and its potential association with clinical outcomes. To this purpose, an exploratory study to detect PCV-4 by molecular methods was performed in Italy and Spain by testing more than 300 samples of different types (serum and tissues), collected from both healthy and diseased pigs and wild boar as well. All samples, independently from the country, type, health status and host, tested PCV-4 negative. Therefore, no evidence of PCV-4 presence was found in Italy and Spain through this exploratory study. Considering the dense pig trade among European countries, its presence in the continent can similarly be considered unlikely. The reasons behind the restricted PCV-4 distribution compared to other porcine circoviruses will require further investigations. Careful surveillance might nevertheless be important since prompt recognition of PCV-4 would allow the implementation of effective countermeasures to prevent its spreading and potential economic losses.
format Online
Article
Text
id pubmed-7350368
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73503682020-07-15 Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain Franzo, Giovanni Ruiz, Albert Grassi, Laura Sibila, Marina Drigo, Michele Segalés, Joaquim Pathogens Communication The genus Circovirus includes several species and mostly causes asymptomatic infections. Porcine circovirus 2 (PCV-2) and, with increasing evidence, Porcine circovirus 3 (PCV-3), have been associated with different clinical conditions all over the world. In 2019, a new porcine circovirus (PCV-4) was identified from diseased animals in China. Because of the lessons learned from PCV-2 and PCV-3, it appears mandatory to investigate the actual distribution of this new virus and its potential association with clinical outcomes. To this purpose, an exploratory study to detect PCV-4 by molecular methods was performed in Italy and Spain by testing more than 300 samples of different types (serum and tissues), collected from both healthy and diseased pigs and wild boar as well. All samples, independently from the country, type, health status and host, tested PCV-4 negative. Therefore, no evidence of PCV-4 presence was found in Italy and Spain through this exploratory study. Considering the dense pig trade among European countries, its presence in the continent can similarly be considered unlikely. The reasons behind the restricted PCV-4 distribution compared to other porcine circoviruses will require further investigations. Careful surveillance might nevertheless be important since prompt recognition of PCV-4 would allow the implementation of effective countermeasures to prevent its spreading and potential economic losses. MDPI 2020-05-31 /pmc/articles/PMC7350368/ /pubmed/32486429 http://dx.doi.org/10.3390/pathogens9060433 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Franzo, Giovanni
Ruiz, Albert
Grassi, Laura
Sibila, Marina
Drigo, Michele
Segalés, Joaquim
Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain
title Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain
title_full Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain
title_fullStr Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain
title_full_unstemmed Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain
title_short Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain
title_sort lack of porcine circovirus 4 genome detection in pig samples from italy and spain
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350368/
https://www.ncbi.nlm.nih.gov/pubmed/32486429
http://dx.doi.org/10.3390/pathogens9060433
work_keys_str_mv AT franzogiovanni lackofporcinecircovirus4genomedetectioninpigsamplesfromitalyandspain
AT ruizalbert lackofporcinecircovirus4genomedetectioninpigsamplesfromitalyandspain
AT grassilaura lackofporcinecircovirus4genomedetectioninpigsamplesfromitalyandspain
AT sibilamarina lackofporcinecircovirus4genomedetectioninpigsamplesfromitalyandspain
AT drigomichele lackofporcinecircovirus4genomedetectioninpigsamplesfromitalyandspain
AT segalesjoaquim lackofporcinecircovirus4genomedetectioninpigsamplesfromitalyandspain