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Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain
The genus Circovirus includes several species and mostly causes asymptomatic infections. Porcine circovirus 2 (PCV-2) and, with increasing evidence, Porcine circovirus 3 (PCV-3), have been associated with different clinical conditions all over the world. In 2019, a new porcine circovirus (PCV-4) was...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350368/ https://www.ncbi.nlm.nih.gov/pubmed/32486429 http://dx.doi.org/10.3390/pathogens9060433 |
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author | Franzo, Giovanni Ruiz, Albert Grassi, Laura Sibila, Marina Drigo, Michele Segalés, Joaquim |
author_facet | Franzo, Giovanni Ruiz, Albert Grassi, Laura Sibila, Marina Drigo, Michele Segalés, Joaquim |
author_sort | Franzo, Giovanni |
collection | PubMed |
description | The genus Circovirus includes several species and mostly causes asymptomatic infections. Porcine circovirus 2 (PCV-2) and, with increasing evidence, Porcine circovirus 3 (PCV-3), have been associated with different clinical conditions all over the world. In 2019, a new porcine circovirus (PCV-4) was identified from diseased animals in China. Because of the lessons learned from PCV-2 and PCV-3, it appears mandatory to investigate the actual distribution of this new virus and its potential association with clinical outcomes. To this purpose, an exploratory study to detect PCV-4 by molecular methods was performed in Italy and Spain by testing more than 300 samples of different types (serum and tissues), collected from both healthy and diseased pigs and wild boar as well. All samples, independently from the country, type, health status and host, tested PCV-4 negative. Therefore, no evidence of PCV-4 presence was found in Italy and Spain through this exploratory study. Considering the dense pig trade among European countries, its presence in the continent can similarly be considered unlikely. The reasons behind the restricted PCV-4 distribution compared to other porcine circoviruses will require further investigations. Careful surveillance might nevertheless be important since prompt recognition of PCV-4 would allow the implementation of effective countermeasures to prevent its spreading and potential economic losses. |
format | Online Article Text |
id | pubmed-7350368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73503682020-07-15 Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain Franzo, Giovanni Ruiz, Albert Grassi, Laura Sibila, Marina Drigo, Michele Segalés, Joaquim Pathogens Communication The genus Circovirus includes several species and mostly causes asymptomatic infections. Porcine circovirus 2 (PCV-2) and, with increasing evidence, Porcine circovirus 3 (PCV-3), have been associated with different clinical conditions all over the world. In 2019, a new porcine circovirus (PCV-4) was identified from diseased animals in China. Because of the lessons learned from PCV-2 and PCV-3, it appears mandatory to investigate the actual distribution of this new virus and its potential association with clinical outcomes. To this purpose, an exploratory study to detect PCV-4 by molecular methods was performed in Italy and Spain by testing more than 300 samples of different types (serum and tissues), collected from both healthy and diseased pigs and wild boar as well. All samples, independently from the country, type, health status and host, tested PCV-4 negative. Therefore, no evidence of PCV-4 presence was found in Italy and Spain through this exploratory study. Considering the dense pig trade among European countries, its presence in the continent can similarly be considered unlikely. The reasons behind the restricted PCV-4 distribution compared to other porcine circoviruses will require further investigations. Careful surveillance might nevertheless be important since prompt recognition of PCV-4 would allow the implementation of effective countermeasures to prevent its spreading and potential economic losses. MDPI 2020-05-31 /pmc/articles/PMC7350368/ /pubmed/32486429 http://dx.doi.org/10.3390/pathogens9060433 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Franzo, Giovanni Ruiz, Albert Grassi, Laura Sibila, Marina Drigo, Michele Segalés, Joaquim Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain |
title | Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain |
title_full | Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain |
title_fullStr | Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain |
title_full_unstemmed | Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain |
title_short | Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain |
title_sort | lack of porcine circovirus 4 genome detection in pig samples from italy and spain |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350368/ https://www.ncbi.nlm.nih.gov/pubmed/32486429 http://dx.doi.org/10.3390/pathogens9060433 |
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