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Research into Neospora caninum—What Have We Learnt in the Last Thirty Years?
Background: Neospora caninum has been recognised world-wide, first as a disease of dogs, then as an important cause of abortions in cattle for the past thirty years. Over that time period, there have been improvements in the diagnosis of infection and abortion, new tests have been developed and vali...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350369/ https://www.ncbi.nlm.nih.gov/pubmed/32585955 http://dx.doi.org/10.3390/pathogens9060505 |
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author | Reichel, Michael P. Wahl, Lloyd C. Ellis, John T. |
author_facet | Reichel, Michael P. Wahl, Lloyd C. Ellis, John T. |
author_sort | Reichel, Michael P. |
collection | PubMed |
description | Background: Neospora caninum has been recognised world-wide, first as a disease of dogs, then as an important cause of abortions in cattle for the past thirty years. Over that time period, there have been improvements in the diagnosis of infection and abortion, new tests have been developed and validated, and it is timely to review progress to date. Methods: Bibliometric methods were used to identify major trends and research topics present in the published literature on N. caninum. The tools used were SWIFT-Review, VOSviewer and SciMAT, along with the published papers found in the MEDLINE, Dimensions and Web of Science databases. A systematic review of the published Neospora literature (n = 2933) was also carried out via MEDLINE and systematically appraised for publications relevant to the pathogenesis, pathology and diagnosis of Neospora abortions. Results: A total of 92 publications were included in the final analysis and grouped into four main time periods. In these four different time periods, the main research themes were “dogs”, “abortion”, “seroprevalence” and “infection”. Diagnostics, including PCR, dominated the first two time periods, with an increased focus on transmission and abortions, and its risk factors in cattle. Conclusions: Longitudinal analyses indicated that the main themes were consistently investigated over the last 30 years through a wide range of studies, with evolving emphasis initially on dogs and diagnostic test development, followed by application to cattle, the identification of the risk factors leading to abortion, and in the latter time periods, an understanding of the immunity and a search for vaccines. |
format | Online Article Text |
id | pubmed-7350369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73503692020-07-15 Research into Neospora caninum—What Have We Learnt in the Last Thirty Years? Reichel, Michael P. Wahl, Lloyd C. Ellis, John T. Pathogens Review Background: Neospora caninum has been recognised world-wide, first as a disease of dogs, then as an important cause of abortions in cattle for the past thirty years. Over that time period, there have been improvements in the diagnosis of infection and abortion, new tests have been developed and validated, and it is timely to review progress to date. Methods: Bibliometric methods were used to identify major trends and research topics present in the published literature on N. caninum. The tools used were SWIFT-Review, VOSviewer and SciMAT, along with the published papers found in the MEDLINE, Dimensions and Web of Science databases. A systematic review of the published Neospora literature (n = 2933) was also carried out via MEDLINE and systematically appraised for publications relevant to the pathogenesis, pathology and diagnosis of Neospora abortions. Results: A total of 92 publications were included in the final analysis and grouped into four main time periods. In these four different time periods, the main research themes were “dogs”, “abortion”, “seroprevalence” and “infection”. Diagnostics, including PCR, dominated the first two time periods, with an increased focus on transmission and abortions, and its risk factors in cattle. Conclusions: Longitudinal analyses indicated that the main themes were consistently investigated over the last 30 years through a wide range of studies, with evolving emphasis initially on dogs and diagnostic test development, followed by application to cattle, the identification of the risk factors leading to abortion, and in the latter time periods, an understanding of the immunity and a search for vaccines. MDPI 2020-06-23 /pmc/articles/PMC7350369/ /pubmed/32585955 http://dx.doi.org/10.3390/pathogens9060505 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Reichel, Michael P. Wahl, Lloyd C. Ellis, John T. Research into Neospora caninum—What Have We Learnt in the Last Thirty Years? |
title | Research into Neospora caninum—What Have We Learnt in the Last Thirty Years? |
title_full | Research into Neospora caninum—What Have We Learnt in the Last Thirty Years? |
title_fullStr | Research into Neospora caninum—What Have We Learnt in the Last Thirty Years? |
title_full_unstemmed | Research into Neospora caninum—What Have We Learnt in the Last Thirty Years? |
title_short | Research into Neospora caninum—What Have We Learnt in the Last Thirty Years? |
title_sort | research into neospora caninum—what have we learnt in the last thirty years? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350369/ https://www.ncbi.nlm.nih.gov/pubmed/32585955 http://dx.doi.org/10.3390/pathogens9060505 |
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