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Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control

Animal tuberculosis (TB) is a multi-host zoonotic disease whose prevalence in cattle herds in Europe has been increasing, despite a huge investment in eradication. The composition of the host community is a fundamental driver of pathogen transmission, and yet this has not been formally quantified fo...

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Autores principales: Santos, Nuno, Richomme, Céline, Nunes, Telmo, Vicente, Joaquín, Alves, Paulo C., de la Fuente, José, Correia-Neves, Margarida, Boschiroli, María-Laura, Delahay, Richard, Gortázar, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350387/
https://www.ncbi.nlm.nih.gov/pubmed/32481701
http://dx.doi.org/10.3390/pathogens9060421
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author Santos, Nuno
Richomme, Céline
Nunes, Telmo
Vicente, Joaquín
Alves, Paulo C.
de la Fuente, José
Correia-Neves, Margarida
Boschiroli, María-Laura
Delahay, Richard
Gortázar, Christian
author_facet Santos, Nuno
Richomme, Céline
Nunes, Telmo
Vicente, Joaquín
Alves, Paulo C.
de la Fuente, José
Correia-Neves, Margarida
Boschiroli, María-Laura
Delahay, Richard
Gortázar, Christian
author_sort Santos, Nuno
collection PubMed
description Animal tuberculosis (TB) is a multi-host zoonotic disease whose prevalence in cattle herds in Europe has been increasing, despite a huge investment in eradication. The composition of the host community is a fundamental driver of pathogen transmission, and yet this has not been formally quantified for animal TB in Europe. We quantified multi-host communities of animal TB, using stochastic models to estimate the number of infected domestic and wild hosts in three regions: officially TB-free Central–Western Europe, and two largely TB-endemic regions, the Iberian Peninsula and Britain and Ireland. We show that the estimated number of infected animals in the three regions was 290,059–1,605,612 and the numbers of infected non-bovine domestic and wild hosts always exceeded those of infected cattle, with ratios ranging from 3.3 (1.3–19.6):1 in Britain and Ireland to 84.3 (20.5–864):1 in the Iberian Peninsula. Our results illustrate for the first time the extent to which animal TB systems in some regions of Europe are dominated by non-bovine domestic and wild species. These findings highlight the need to adapt current strategies for effective future control of the disease.
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spelling pubmed-73503872020-07-15 Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control Santos, Nuno Richomme, Céline Nunes, Telmo Vicente, Joaquín Alves, Paulo C. de la Fuente, José Correia-Neves, Margarida Boschiroli, María-Laura Delahay, Richard Gortázar, Christian Pathogens Article Animal tuberculosis (TB) is a multi-host zoonotic disease whose prevalence in cattle herds in Europe has been increasing, despite a huge investment in eradication. The composition of the host community is a fundamental driver of pathogen transmission, and yet this has not been formally quantified for animal TB in Europe. We quantified multi-host communities of animal TB, using stochastic models to estimate the number of infected domestic and wild hosts in three regions: officially TB-free Central–Western Europe, and two largely TB-endemic regions, the Iberian Peninsula and Britain and Ireland. We show that the estimated number of infected animals in the three regions was 290,059–1,605,612 and the numbers of infected non-bovine domestic and wild hosts always exceeded those of infected cattle, with ratios ranging from 3.3 (1.3–19.6):1 in Britain and Ireland to 84.3 (20.5–864):1 in the Iberian Peninsula. Our results illustrate for the first time the extent to which animal TB systems in some regions of Europe are dominated by non-bovine domestic and wild species. These findings highlight the need to adapt current strategies for effective future control of the disease. MDPI 2020-05-28 /pmc/articles/PMC7350387/ /pubmed/32481701 http://dx.doi.org/10.3390/pathogens9060421 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Santos, Nuno
Richomme, Céline
Nunes, Telmo
Vicente, Joaquín
Alves, Paulo C.
de la Fuente, José
Correia-Neves, Margarida
Boschiroli, María-Laura
Delahay, Richard
Gortázar, Christian
Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control
title Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control
title_full Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control
title_fullStr Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control
title_full_unstemmed Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control
title_short Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control
title_sort quantification of the animal tuberculosis multi-host community offers insights for control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350387/
https://www.ncbi.nlm.nih.gov/pubmed/32481701
http://dx.doi.org/10.3390/pathogens9060421
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