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Biomarkers of Brain Damage Induced by Radiotherapy
Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350401/ https://www.ncbi.nlm.nih.gov/pubmed/32694960 http://dx.doi.org/10.1177/1559325820938279 |
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author | Sultana, Nahida Sun, Chao Katsube, Takanori Wang, Bing |
author_facet | Sultana, Nahida Sun, Chao Katsube, Takanori Wang, Bing |
author_sort | Sultana, Nahida |
collection | PubMed |
description | Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is, development of cognitive impairments following cranial radiotherapy is considered as a critical clinical disadvantage especially for the whole brain radiotherapy. Biomarkers can help to detect the accurate physiology or conditions of patients with brain tumor and develop effective treatment procedures for these patients. In the near future, biomarkers will become one of the prime driving forces of cancer treatment. In this minireview, we analyze the documented work on the acute brain damage and late consequences induced by radiotherapy, identify the biomarkers, in particular, the predictive biomarkers for the damage, and summarize the biological significance of the biomarkers. It is expected that translation of these research advance to radiotherapy would assist stratifying patients for optimized treatment and improving therapeutic efficacy and the quality of life. |
format | Online Article Text |
id | pubmed-7350401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-73504012020-07-20 Biomarkers of Brain Damage Induced by Radiotherapy Sultana, Nahida Sun, Chao Katsube, Takanori Wang, Bing Dose Response Potential Biomarkers of Radiation Damage Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is, development of cognitive impairments following cranial radiotherapy is considered as a critical clinical disadvantage especially for the whole brain radiotherapy. Biomarkers can help to detect the accurate physiology or conditions of patients with brain tumor and develop effective treatment procedures for these patients. In the near future, biomarkers will become one of the prime driving forces of cancer treatment. In this minireview, we analyze the documented work on the acute brain damage and late consequences induced by radiotherapy, identify the biomarkers, in particular, the predictive biomarkers for the damage, and summarize the biological significance of the biomarkers. It is expected that translation of these research advance to radiotherapy would assist stratifying patients for optimized treatment and improving therapeutic efficacy and the quality of life. SAGE Publications 2020-07-09 /pmc/articles/PMC7350401/ /pubmed/32694960 http://dx.doi.org/10.1177/1559325820938279 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Potential Biomarkers of Radiation Damage Sultana, Nahida Sun, Chao Katsube, Takanori Wang, Bing Biomarkers of Brain Damage Induced by Radiotherapy |
title | Biomarkers of Brain Damage Induced by Radiotherapy |
title_full | Biomarkers of Brain Damage Induced by Radiotherapy |
title_fullStr | Biomarkers of Brain Damage Induced by Radiotherapy |
title_full_unstemmed | Biomarkers of Brain Damage Induced by Radiotherapy |
title_short | Biomarkers of Brain Damage Induced by Radiotherapy |
title_sort | biomarkers of brain damage induced by radiotherapy |
topic | Potential Biomarkers of Radiation Damage |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350401/ https://www.ncbi.nlm.nih.gov/pubmed/32694960 http://dx.doi.org/10.1177/1559325820938279 |
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