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Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study
BACKGROUND: There has been scanty data regarding the clinical significance of tumor conspicuity in pancreatic cancer. In this study, we attempted to investigate the prognostic significance of pancreatic tumor conspicuity and determine prognostic factors for postoperative recurrence in patients with...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350737/ https://www.ncbi.nlm.nih.gov/pubmed/32650842 http://dx.doi.org/10.1186/s40644-020-00321-2 |
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author | Yoo, Hye Jin You, Myung-Won Han, Dong Yoon Hwang, Ji Hye Park, Seong Jin |
author_facet | Yoo, Hye Jin You, Myung-Won Han, Dong Yoon Hwang, Ji Hye Park, Seong Jin |
author_sort | Yoo, Hye Jin |
collection | PubMed |
description | BACKGROUND: There has been scanty data regarding the clinical significance of tumor conspicuity in pancreatic cancer. In this study, we attempted to investigate the prognostic significance of pancreatic tumor conspicuity and determine prognostic factors for postoperative recurrence in patients with surgically resected pancreatic cancer. METHODS: Between January 2011 and September 2019, 62 patients who underwent preoperative computed tomography (CT) for pancreatic cancer were retrospectively included. Two reviewers evaluated various clinical, imaging, and pathologic variables and reviewed all available medical records to determine patient outcomes after surgery. Tumor conspicuity was defined as the attenuation ratio between normal parenchyma and tumor lesions on dynamic-enhanced CT images and represented the conspicuity score. Recurrence-free survival and overall survival were investigated using Cox regression analysis. RESULTS: Patient mean age was 65.9 (±11.6) years, and 56.5% were male. The median follow-up period was 11 months (range 2–138). Forty patients (64.5%) experienced postoperative recurrence, and the median time to recurrence was 6 months (range 1–101). Tumor conspicuity scores were positively correlated with both radiologic and pathologic tumor sizes (r = 0.252, 0.321, p < 0.01). Conspicuity score ≥ 2 (HR 3.8, 95% CI 1.73–8.47), elevated preoperative (HR 1.15, 95% CI; 1.02–1.28) and postoperative CA19–9 (HR 1.11, 95% CI 1.01–1.23), pathologic tumor size (HR 1.61, 95% CI 1.06–2.45), and lymphatic invasion (HR 2.76, 95% CI 1.22–6.21) were significant factors for recurrence-free survival in the multivariate analysis. CONCLUSIONS: Over half of the patients with pancreatic cancer experienced postoperative recurrence (64.5%). Increased tumor conspicuity correlated with larger tumor size and postoperative recurrence. |
format | Online Article Text |
id | pubmed-7350737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73507372020-07-14 Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study Yoo, Hye Jin You, Myung-Won Han, Dong Yoon Hwang, Ji Hye Park, Seong Jin Cancer Imaging Research Article BACKGROUND: There has been scanty data regarding the clinical significance of tumor conspicuity in pancreatic cancer. In this study, we attempted to investigate the prognostic significance of pancreatic tumor conspicuity and determine prognostic factors for postoperative recurrence in patients with surgically resected pancreatic cancer. METHODS: Between January 2011 and September 2019, 62 patients who underwent preoperative computed tomography (CT) for pancreatic cancer were retrospectively included. Two reviewers evaluated various clinical, imaging, and pathologic variables and reviewed all available medical records to determine patient outcomes after surgery. Tumor conspicuity was defined as the attenuation ratio between normal parenchyma and tumor lesions on dynamic-enhanced CT images and represented the conspicuity score. Recurrence-free survival and overall survival were investigated using Cox regression analysis. RESULTS: Patient mean age was 65.9 (±11.6) years, and 56.5% were male. The median follow-up period was 11 months (range 2–138). Forty patients (64.5%) experienced postoperative recurrence, and the median time to recurrence was 6 months (range 1–101). Tumor conspicuity scores were positively correlated with both radiologic and pathologic tumor sizes (r = 0.252, 0.321, p < 0.01). Conspicuity score ≥ 2 (HR 3.8, 95% CI 1.73–8.47), elevated preoperative (HR 1.15, 95% CI; 1.02–1.28) and postoperative CA19–9 (HR 1.11, 95% CI 1.01–1.23), pathologic tumor size (HR 1.61, 95% CI 1.06–2.45), and lymphatic invasion (HR 2.76, 95% CI 1.22–6.21) were significant factors for recurrence-free survival in the multivariate analysis. CONCLUSIONS: Over half of the patients with pancreatic cancer experienced postoperative recurrence (64.5%). Increased tumor conspicuity correlated with larger tumor size and postoperative recurrence. BioMed Central 2020-07-10 /pmc/articles/PMC7350737/ /pubmed/32650842 http://dx.doi.org/10.1186/s40644-020-00321-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Yoo, Hye Jin You, Myung-Won Han, Dong Yoon Hwang, Ji Hye Park, Seong Jin Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study |
title | Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study |
title_full | Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study |
title_fullStr | Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study |
title_full_unstemmed | Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study |
title_short | Tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study |
title_sort | tumor conspicuity significantly correlates with postoperative recurrence in patients with pancreatic cancer: a retrospective observational study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350737/ https://www.ncbi.nlm.nih.gov/pubmed/32650842 http://dx.doi.org/10.1186/s40644-020-00321-2 |
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