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Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders

BACKGROUND: To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions. METHODS: Consecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation...

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Autores principales: Chehaibou, Ismael, Pettenkofer, Moritz, Govetto, Andrea, Rabina, Gilad, Sadda, SriniVas R., Hubschman, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350739/
https://www.ncbi.nlm.nih.gov/pubmed/32670614
http://dx.doi.org/10.1186/s40942-020-00233-0
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author Chehaibou, Ismael
Pettenkofer, Moritz
Govetto, Andrea
Rabina, Gilad
Sadda, SriniVas R.
Hubschman, Jean-Pierre
author_facet Chehaibou, Ismael
Pettenkofer, Moritz
Govetto, Andrea
Rabina, Gilad
Sadda, SriniVas R.
Hubschman, Jean-Pierre
author_sort Chehaibou, Ismael
collection PubMed
description BACKGROUND: To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions. METHODS: Consecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation on optical coherence tomography (OCT) were enrolled in this cross-sectional study. Included patients were divided into two groups: vitreoretinal interface pathologies group or retinal diseases group. Presence of epiretinal proliferation and its localization within the 9 macular sectors, as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS), were assessed on OCT. RESULTS: 77 eyes from 69 patients demonstrated epiretinal proliferation on OCT. The most frequently involved ETDRS sector was the 1-mm central subfield, followed by inner temporal and inner nasal sectors. Localization of epiretinal proliferation correlated with the presence of any retinal abnormalities in the same quadrant (r = 0.962; P < 0.0001). 31 eyes (40.3%) demonstrated symptomatic vitreoretinal interface pathologies including lamellar macular hole, full-thickness macular hole, epiretinal membrane and history of macular peeling. 46 eyes (59.7%) manifested various retinal diseases, including age-related macular degeneration, diabetic retinopathy, refractory macular edema, vein occlusion and high myopia. CONCLUSIONS: Epiretinal proliferation was noted in several retinal conditions and not limited only to full-thickness and lamellar macular holes. Different mechanisms affecting retinal homeostasis might trigger Müller cells dysregulation, potentially leading to abnormal retinal remodeling.
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spelling pubmed-73507392020-07-14 Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders Chehaibou, Ismael Pettenkofer, Moritz Govetto, Andrea Rabina, Gilad Sadda, SriniVas R. Hubschman, Jean-Pierre Int J Retina Vitreous Original Article BACKGROUND: To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions. METHODS: Consecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation on optical coherence tomography (OCT) were enrolled in this cross-sectional study. Included patients were divided into two groups: vitreoretinal interface pathologies group or retinal diseases group. Presence of epiretinal proliferation and its localization within the 9 macular sectors, as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS), were assessed on OCT. RESULTS: 77 eyes from 69 patients demonstrated epiretinal proliferation on OCT. The most frequently involved ETDRS sector was the 1-mm central subfield, followed by inner temporal and inner nasal sectors. Localization of epiretinal proliferation correlated with the presence of any retinal abnormalities in the same quadrant (r = 0.962; P < 0.0001). 31 eyes (40.3%) demonstrated symptomatic vitreoretinal interface pathologies including lamellar macular hole, full-thickness macular hole, epiretinal membrane and history of macular peeling. 46 eyes (59.7%) manifested various retinal diseases, including age-related macular degeneration, diabetic retinopathy, refractory macular edema, vein occlusion and high myopia. CONCLUSIONS: Epiretinal proliferation was noted in several retinal conditions and not limited only to full-thickness and lamellar macular holes. Different mechanisms affecting retinal homeostasis might trigger Müller cells dysregulation, potentially leading to abnormal retinal remodeling. BioMed Central 2020-07-10 /pmc/articles/PMC7350739/ /pubmed/32670614 http://dx.doi.org/10.1186/s40942-020-00233-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Original Article
Chehaibou, Ismael
Pettenkofer, Moritz
Govetto, Andrea
Rabina, Gilad
Sadda, SriniVas R.
Hubschman, Jean-Pierre
Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
title Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
title_full Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
title_fullStr Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
title_full_unstemmed Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
title_short Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
title_sort identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350739/
https://www.ncbi.nlm.nih.gov/pubmed/32670614
http://dx.doi.org/10.1186/s40942-020-00233-0
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