A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

BACKGROUND: Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, affects OA...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Xing, Dan, Wang, Yawei, Jia, Haobo, Li, Bing, Li, Jiao Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350747/
https://www.ncbi.nlm.nih.gov/pubmed/32650720
http://dx.doi.org/10.1186/s12860-020-00299-6

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