Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease

BACKGROUND/AIM: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. MATERIALS AND METHODS: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a...

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Detalles Bibliográficos
Autores principales: KESKİN, Gül Sema, HELVACI, Özant, YAYLA, Çağrı, T. PAŞAOĞLU, Özge, KESKİN, Çağlar, ARINSOY, Turgay, B. DERİCİ, Ülver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350791/
https://www.ncbi.nlm.nih.gov/pubmed/30763987
http://dx.doi.org/10.3906/sag-1804-169
Descripción
Sumario:BACKGROUND/AIM: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. MATERIALS AND METHODS: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. RESULTS: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = –0.674 and r = –0.471, respectively). CONCLUSION: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.

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