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The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients
BACKGROUND/AIM: Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific and Technological Research Council of Turkey
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350794/ https://www.ncbi.nlm.nih.gov/pubmed/30761880 http://dx.doi.org/10.3906/sag-1806-44 |
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author | SOYUDURU, Gonca ÖZSOY ADIŞEN, Esra KADIOĞLU ÖZER, İlkay A. AKSAKAL, Burhan |
author_facet | SOYUDURU, Gonca ÖZSOY ADIŞEN, Esra KADIOĞLU ÖZER, İlkay A. AKSAKAL, Burhan |
author_sort | SOYUDURU, Gonca |
collection | PubMed |
description | BACKGROUND/AIM: Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels. MATERIALS AND METHODS: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment. RESULTS: In AV patients, pretreatment HOMA-IR and adipocytokine levels were not found to correlate with disease severity. With five months of isotretinoin treatment, higher HOMA-IR values were found (P = 0.028). Isotretinoin therapy maintained lower mean resistin levels (P = 0.016), higher mean RBP4 levels (P = 0.040), but not affected the mean adiponectin and leptin levels (P = 0.113, P = 0.125, respectively). CONCLUSIONS: All data suggests that five months of isotretinoin therapy in AV patients causes insulin resistance and the increase in insulin resistance is not dependent on age, BMI, BFM, and lipid levels of these patients. |
format | Online Article Text |
id | pubmed-7350794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-73507942020-07-13 The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients SOYUDURU, Gonca ÖZSOY ADIŞEN, Esra KADIOĞLU ÖZER, İlkay A. AKSAKAL, Burhan Turk J Med Sci Article BACKGROUND/AIM: Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels. MATERIALS AND METHODS: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment. RESULTS: In AV patients, pretreatment HOMA-IR and adipocytokine levels were not found to correlate with disease severity. With five months of isotretinoin treatment, higher HOMA-IR values were found (P = 0.028). Isotretinoin therapy maintained lower mean resistin levels (P = 0.016), higher mean RBP4 levels (P = 0.040), but not affected the mean adiponectin and leptin levels (P = 0.113, P = 0.125, respectively). CONCLUSIONS: All data suggests that five months of isotretinoin therapy in AV patients causes insulin resistance and the increase in insulin resistance is not dependent on age, BMI, BFM, and lipid levels of these patients. The Scientific and Technological Research Council of Turkey 2019-02-11 /pmc/articles/PMC7350794/ /pubmed/30761880 http://dx.doi.org/10.3906/sag-1806-44 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article SOYUDURU, Gonca ÖZSOY ADIŞEN, Esra KADIOĞLU ÖZER, İlkay A. AKSAKAL, Burhan The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients |
title | The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients |
title_full | The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients |
title_fullStr | The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients |
title_full_unstemmed | The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients |
title_short | The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients |
title_sort | effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350794/ https://www.ncbi.nlm.nih.gov/pubmed/30761880 http://dx.doi.org/10.3906/sag-1806-44 |
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