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Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
BACKGROUND/AIM: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic ki...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific and Technological Research Council of Turkey
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350863/ https://www.ncbi.nlm.nih.gov/pubmed/30761853 http://dx.doi.org/10.3906/sag-1809-43 |
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author | MUTLUAY, Rüya KONCA DEĞERTEKİN, Ceyla IŞIKTAŞ SAYILAR, Emel DERİCİ, Ülver GÜLTEKİN, Serap GÖNEN, Sevim ARINSOY, Selim Turgay SİNDEL, Mahmut Şükrü |
author_facet | MUTLUAY, Rüya KONCA DEĞERTEKİN, Ceyla IŞIKTAŞ SAYILAR, Emel DERİCİ, Ülver GÜLTEKİN, Serap GÖNEN, Sevim ARINSOY, Selim Turgay SİNDEL, Mahmut Şükrü |
author_sort | MUTLUAY, Rüya |
collection | PubMed |
description | BACKGROUND/AIM: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). MATERIALS AND METHODS: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained. RESULTS: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower than those in patients with stage-3 and stage-4 CKD (stage-5 vs. stage-4, P < 0.001; stage-5 vs. stage-3, P < 0.001). Fetuin-A was negatively correlated with creatinine (P < 0.001), Ca × P product (P < 0.001), hs-CRP (P = 0.01), vascular calcification score (P < 0.001), and CIMT (P < 0.001), and positively correlated with BMI (P < 0.001, r = 0.30) and serum albumin (P < 0.001). CONCLUSION: Lower levels of fetuin-A were associated with higher vascular calcification scores, CIMT, hs-CRP levels, and lower BMI and albumin. Fetuin-A deficiency may be a key element for MIAC syndrome. |
format | Online Article Text |
id | pubmed-7350863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-73508632020-07-13 Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease MUTLUAY, Rüya KONCA DEĞERTEKİN, Ceyla IŞIKTAŞ SAYILAR, Emel DERİCİ, Ülver GÜLTEKİN, Serap GÖNEN, Sevim ARINSOY, Selim Turgay SİNDEL, Mahmut Şükrü Turk J Med Sci Article BACKGROUND/AIM: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). MATERIALS AND METHODS: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained. RESULTS: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower than those in patients with stage-3 and stage-4 CKD (stage-5 vs. stage-4, P < 0.001; stage-5 vs. stage-3, P < 0.001). Fetuin-A was negatively correlated with creatinine (P < 0.001), Ca × P product (P < 0.001), hs-CRP (P = 0.01), vascular calcification score (P < 0.001), and CIMT (P < 0.001), and positively correlated with BMI (P < 0.001, r = 0.30) and serum albumin (P < 0.001). CONCLUSION: Lower levels of fetuin-A were associated with higher vascular calcification scores, CIMT, hs-CRP levels, and lower BMI and albumin. Fetuin-A deficiency may be a key element for MIAC syndrome. The Scientific and Technological Research Council of Turkey 2019-02-11 /pmc/articles/PMC7350863/ /pubmed/30761853 http://dx.doi.org/10.3906/sag-1809-43 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article MUTLUAY, Rüya KONCA DEĞERTEKİN, Ceyla IŞIKTAŞ SAYILAR, Emel DERİCİ, Ülver GÜLTEKİN, Serap GÖNEN, Sevim ARINSOY, Selim Turgay SİNDEL, Mahmut Şükrü Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease |
title | Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease |
title_full | Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease |
title_fullStr | Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease |
title_full_unstemmed | Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease |
title_short | Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease |
title_sort | serum fetuin-a is associated with the components of miac(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350863/ https://www.ncbi.nlm.nih.gov/pubmed/30761853 http://dx.doi.org/10.3906/sag-1809-43 |
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