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Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease

BACKGROUND/AIM: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic ki...

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Autores principales: MUTLUAY, Rüya, KONCA DEĞERTEKİN, Ceyla, IŞIKTAŞ SAYILAR, Emel, DERİCİ, Ülver, GÜLTEKİN, Serap, GÖNEN, Sevim, ARINSOY, Selim Turgay, SİNDEL, Mahmut Şükrü
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350863/
https://www.ncbi.nlm.nih.gov/pubmed/30761853
http://dx.doi.org/10.3906/sag-1809-43
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author MUTLUAY, Rüya
KONCA DEĞERTEKİN, Ceyla
IŞIKTAŞ SAYILAR, Emel
DERİCİ, Ülver
GÜLTEKİN, Serap
GÖNEN, Sevim
ARINSOY, Selim Turgay
SİNDEL, Mahmut Şükrü
author_facet MUTLUAY, Rüya
KONCA DEĞERTEKİN, Ceyla
IŞIKTAŞ SAYILAR, Emel
DERİCİ, Ülver
GÜLTEKİN, Serap
GÖNEN, Sevim
ARINSOY, Selim Turgay
SİNDEL, Mahmut Şükrü
author_sort MUTLUAY, Rüya
collection PubMed
description BACKGROUND/AIM: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). MATERIALS AND METHODS: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained. RESULTS: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower than those in patients with stage-3 and stage-4 CKD (stage-5 vs. stage-4, P < 0.001; stage-5 vs. stage-3, P < 0.001). Fetuin-A was negatively correlated with creatinine (P < 0.001), Ca × P product (P < 0.001), hs-CRP (P = 0.01), vascular calcification score (P < 0.001), and CIMT (P < 0.001), and positively correlated with BMI (P < 0.001, r = 0.30) and serum albumin (P < 0.001). CONCLUSION: Lower levels of fetuin-A were associated with higher vascular calcification scores, CIMT, hs-CRP levels, and lower BMI and albumin. Fetuin-A deficiency may be a key element for MIAC syndrome.
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spelling pubmed-73508632020-07-13 Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease MUTLUAY, Rüya KONCA DEĞERTEKİN, Ceyla IŞIKTAŞ SAYILAR, Emel DERİCİ, Ülver GÜLTEKİN, Serap GÖNEN, Sevim ARINSOY, Selim Turgay SİNDEL, Mahmut Şükrü Turk J Med Sci Article BACKGROUND/AIM: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). MATERIALS AND METHODS: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained. RESULTS: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower than those in patients with stage-3 and stage-4 CKD (stage-5 vs. stage-4, P < 0.001; stage-5 vs. stage-3, P < 0.001). Fetuin-A was negatively correlated with creatinine (P < 0.001), Ca × P product (P < 0.001), hs-CRP (P = 0.01), vascular calcification score (P < 0.001), and CIMT (P < 0.001), and positively correlated with BMI (P < 0.001, r = 0.30) and serum albumin (P < 0.001). CONCLUSION: Lower levels of fetuin-A were associated with higher vascular calcification scores, CIMT, hs-CRP levels, and lower BMI and albumin. Fetuin-A deficiency may be a key element for MIAC syndrome. The Scientific and Technological Research Council of Turkey 2019-02-11 /pmc/articles/PMC7350863/ /pubmed/30761853 http://dx.doi.org/10.3906/sag-1809-43 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
MUTLUAY, Rüya
KONCA DEĞERTEKİN, Ceyla
IŞIKTAŞ SAYILAR, Emel
DERİCİ, Ülver
GÜLTEKİN, Serap
GÖNEN, Sevim
ARINSOY, Selim Turgay
SİNDEL, Mahmut Şükrü
Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
title Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
title_full Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
title_fullStr Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
title_full_unstemmed Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
title_short Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
title_sort serum fetuin-a is associated with the components of miac(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350863/
https://www.ncbi.nlm.nih.gov/pubmed/30761853
http://dx.doi.org/10.3906/sag-1809-43
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