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Immune Thrombocytopenic Purpura in Patients with COVID-19

We described three COVID-19-infected patients with profound immune thrombocytopenia causing haemorrhagic mucocutaneous complications. We conclude that an immune mechanism was responsible as common causes were excluded. Since corticoids were considered harmful in the circumstances, the patients were...

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Autores principales: Revuz, Sabine, Vernier, Nathalie, Saadi, Leilah, Campagne, Julien, Poussing, Sophie, Maurier, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350967/
https://www.ncbi.nlm.nih.gov/pubmed/32665935
http://dx.doi.org/10.12890/2020_001751
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author Revuz, Sabine
Vernier, Nathalie
Saadi, Leilah
Campagne, Julien
Poussing, Sophie
Maurier, François
author_facet Revuz, Sabine
Vernier, Nathalie
Saadi, Leilah
Campagne, Julien
Poussing, Sophie
Maurier, François
author_sort Revuz, Sabine
collection PubMed
description We described three COVID-19-infected patients with profound immune thrombocytopenia causing haemorrhagic mucocutaneous complications. We conclude that an immune mechanism was responsible as common causes were excluded. Since corticoids were considered harmful in the circumstances, the patients were successfully treated with intravenous immunoglobulins without later relapse. LEARNING POINTS: The severity of haemorrhagic syndrome is not correlated with the severity of COVID-19 infection. Thrombocytopenia in mild COVID-19 infection seems to have an autoimmune mechanism. Intravenous immunoglobulins (1 g/kg) should be the first line of treatment.
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spelling pubmed-73509672020-07-13 Immune Thrombocytopenic Purpura in Patients with COVID-19 Revuz, Sabine Vernier, Nathalie Saadi, Leilah Campagne, Julien Poussing, Sophie Maurier, François Eur J Case Rep Intern Med Articles We described three COVID-19-infected patients with profound immune thrombocytopenia causing haemorrhagic mucocutaneous complications. We conclude that an immune mechanism was responsible as common causes were excluded. Since corticoids were considered harmful in the circumstances, the patients were successfully treated with intravenous immunoglobulins without later relapse. LEARNING POINTS: The severity of haemorrhagic syndrome is not correlated with the severity of COVID-19 infection. Thrombocytopenia in mild COVID-19 infection seems to have an autoimmune mechanism. Intravenous immunoglobulins (1 g/kg) should be the first line of treatment. SMC Media Srl 2020-06-09 /pmc/articles/PMC7350967/ /pubmed/32665935 http://dx.doi.org/10.12890/2020_001751 Text en © EFIM 2020 This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Articles
Revuz, Sabine
Vernier, Nathalie
Saadi, Leilah
Campagne, Julien
Poussing, Sophie
Maurier, François
Immune Thrombocytopenic Purpura in Patients with COVID-19
title Immune Thrombocytopenic Purpura in Patients with COVID-19
title_full Immune Thrombocytopenic Purpura in Patients with COVID-19
title_fullStr Immune Thrombocytopenic Purpura in Patients with COVID-19
title_full_unstemmed Immune Thrombocytopenic Purpura in Patients with COVID-19
title_short Immune Thrombocytopenic Purpura in Patients with COVID-19
title_sort immune thrombocytopenic purpura in patients with covid-19
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350967/
https://www.ncbi.nlm.nih.gov/pubmed/32665935
http://dx.doi.org/10.12890/2020_001751
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