Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia

BACKGROUND: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19). CASE DESCRIPTION: We describe a patient with rapid worsening of COVID-19 pneumonia and...

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Autores principales: Ruch, Yvon, Kaeuffer, Charlotte, Guffroy, Aurélien, Lefebvre, Nicolas, Hansmann, Yves, Danion, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350974/
https://www.ncbi.nlm.nih.gov/pubmed/32665942
http://dx.doi.org/10.12890/2020_001822
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author Ruch, Yvon
Kaeuffer, Charlotte
Guffroy, Aurélien
Lefebvre, Nicolas
Hansmann, Yves
Danion, François
author_facet Ruch, Yvon
Kaeuffer, Charlotte
Guffroy, Aurélien
Lefebvre, Nicolas
Hansmann, Yves
Danion, François
author_sort Ruch, Yvon
collection PubMed
description BACKGROUND: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19). CASE DESCRIPTION: We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids. DISCUSSION: Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome. LEARNING POINTS: One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation. Corticosteroid therapy may be useful in these patients.
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spelling pubmed-73509742020-07-13 Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia Ruch, Yvon Kaeuffer, Charlotte Guffroy, Aurélien Lefebvre, Nicolas Hansmann, Yves Danion, François Eur J Case Rep Intern Med Articles BACKGROUND: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19). CASE DESCRIPTION: We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids. DISCUSSION: Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome. LEARNING POINTS: One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation. Corticosteroid therapy may be useful in these patients. SMC Media Srl 2020-07-02 /pmc/articles/PMC7350974/ /pubmed/32665942 http://dx.doi.org/10.12890/2020_001822 Text en © EFIM 2020 This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Articles
Ruch, Yvon
Kaeuffer, Charlotte
Guffroy, Aurélien
Lefebvre, Nicolas
Hansmann, Yves
Danion, François
Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
title Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
title_full Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
title_fullStr Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
title_full_unstemmed Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
title_short Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
title_sort rapid radiological worsening and cytokine storm syndrome in covid-19 pneumonia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350974/
https://www.ncbi.nlm.nih.gov/pubmed/32665942
http://dx.doi.org/10.12890/2020_001822
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