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Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions
The earliest possible diagnosis and understanding of the infection mechanisms play a crucial role in the outcome of fighting viral diseases. Thus, we designed and developed for the first time, novel bioconjugates made of Ag-In-S@ZnS (ZAIS) fluorescent quantum dots coupled with ZIKA virus via covalen...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351043/ https://www.ncbi.nlm.nih.gov/pubmed/32834256 http://dx.doi.org/10.1016/j.matlet.2020.128279 |
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author | Carvalho, Sandhra M. Mansur, Alexandra A.P. Carvalho, Isadora C. Costa, Érica A. Guedes, Maria Isabel M.C. Kroon, Erna G. Lobato, Zelia I.P. Mansur, Herman S. |
author_facet | Carvalho, Sandhra M. Mansur, Alexandra A.P. Carvalho, Isadora C. Costa, Érica A. Guedes, Maria Isabel M.C. Kroon, Erna G. Lobato, Zelia I.P. Mansur, Herman S. |
author_sort | Carvalho, Sandhra M. |
collection | PubMed |
description | The earliest possible diagnosis and understanding of the infection mechanisms play a crucial role in the outcome of fighting viral diseases. Thus, we designed and developed for the first time, novel bioconjugates made of Ag-In-S@ZnS (ZAIS) fluorescent quantum dots coupled with ZIKA virus via covalent amide bond with carboxymethylcellulose (CMC) biopolymer for labeling and bioimaging the virus-host cell interactions mechanisms through confocal laser scanning microscopy. This work offers relevant insights regarding the profile of the ZIKA virus-nanoparticle conjugates interactions with VERO cells, which can be applied as a nanoplatform to elucidate the infection mechanisms caused by this viral disease. |
format | Online Article Text |
id | pubmed-7351043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73510432020-07-13 Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions Carvalho, Sandhra M. Mansur, Alexandra A.P. Carvalho, Isadora C. Costa, Érica A. Guedes, Maria Isabel M.C. Kroon, Erna G. Lobato, Zelia I.P. Mansur, Herman S. Mater Lett Article The earliest possible diagnosis and understanding of the infection mechanisms play a crucial role in the outcome of fighting viral diseases. Thus, we designed and developed for the first time, novel bioconjugates made of Ag-In-S@ZnS (ZAIS) fluorescent quantum dots coupled with ZIKA virus via covalent amide bond with carboxymethylcellulose (CMC) biopolymer for labeling and bioimaging the virus-host cell interactions mechanisms through confocal laser scanning microscopy. This work offers relevant insights regarding the profile of the ZIKA virus-nanoparticle conjugates interactions with VERO cells, which can be applied as a nanoplatform to elucidate the infection mechanisms caused by this viral disease. Elsevier B.V. 2020-10-15 2020-07-10 /pmc/articles/PMC7351043/ /pubmed/32834256 http://dx.doi.org/10.1016/j.matlet.2020.128279 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Carvalho, Sandhra M. Mansur, Alexandra A.P. Carvalho, Isadora C. Costa, Érica A. Guedes, Maria Isabel M.C. Kroon, Erna G. Lobato, Zelia I.P. Mansur, Herman S. Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions |
title | Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions |
title_full | Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions |
title_fullStr | Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions |
title_full_unstemmed | Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions |
title_short | Fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions |
title_sort | fluorescent quantum dots-zika virus hybrid nanoconjugates for biolabeling, bioimaging, and tracking host-cell interactions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351043/ https://www.ncbi.nlm.nih.gov/pubmed/32834256 http://dx.doi.org/10.1016/j.matlet.2020.128279 |
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