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Comorbidities associated with non- healing of plantar ulcers in leprosy patients

BACKGROUND: Non-healing plantar ulcers are one of the significant causes of disability in leprosy patients. Plantar ulcers often take months or years to heal, affecting the patient’s quality of life. Presence of comorbid conditions in these patients can delay wound healing. The study aimed to evalua...

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Autores principales: Upputuri, Brahmaiah, Srikantam, Aparna, Mamidi, Raja Sriswan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351235/
https://www.ncbi.nlm.nih.gov/pubmed/32598386
http://dx.doi.org/10.1371/journal.pntd.0008393
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author Upputuri, Brahmaiah
Srikantam, Aparna
Mamidi, Raja Sriswan
author_facet Upputuri, Brahmaiah
Srikantam, Aparna
Mamidi, Raja Sriswan
author_sort Upputuri, Brahmaiah
collection PubMed
description BACKGROUND: Non-healing plantar ulcers are one of the significant causes of disability in leprosy patients. Plantar ulcers often take months or years to heal, affecting the patient’s quality of life. Presence of comorbid conditions in these patients can delay wound healing. The study aimed to evaluate the role of associated comorbid conditions as risk factors in ulcer healing. METHODOLOGY/PRINCIPAL FINDINGS: A total of 66 leprosy patients with plantar ulcers registered at LEPRA Society-Blue Peter Public Health and Research Center (BPHRC), Hyderabad, India from June 2018 to June 2019 were studied. Comprehensive clinical assessment was done, including screening for comorbid conditions and treated as per the recommended guidelines. About two-thirds of the participants were aged 50 and above, of which more than half were illiterates, and 93.5% were living below the poverty line. Majority of ulcers were seen on the forefoot; with the head of meta-tarsal bone 27 (41.6%) as the commonest site, followed by calcaneum 23 (38.3%) and great toe 10 (16.6%). Mean ulcer depth was 0.61 (0.57) cm, the area was 5.24 (6.73) cm(2) and ulcer volume was 4.72 (14.33) cm(3). Ulcer dimensions were significantly associated with low body mass index, hypertension and smoking. CONCLUSIONS/SIGNIFICANCE: Identifying the risk factors delaying wound healing and detailed assessment of ulcers are of profound importance to predict the outcome of plantar ulcers in leprosy patients. The study findings indicate the need for better policies by the leprosy control program for the comprehensive management of plantar ulcers.
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spelling pubmed-73512352020-07-22 Comorbidities associated with non- healing of plantar ulcers in leprosy patients Upputuri, Brahmaiah Srikantam, Aparna Mamidi, Raja Sriswan PLoS Negl Trop Dis Research Article BACKGROUND: Non-healing plantar ulcers are one of the significant causes of disability in leprosy patients. Plantar ulcers often take months or years to heal, affecting the patient’s quality of life. Presence of comorbid conditions in these patients can delay wound healing. The study aimed to evaluate the role of associated comorbid conditions as risk factors in ulcer healing. METHODOLOGY/PRINCIPAL FINDINGS: A total of 66 leprosy patients with plantar ulcers registered at LEPRA Society-Blue Peter Public Health and Research Center (BPHRC), Hyderabad, India from June 2018 to June 2019 were studied. Comprehensive clinical assessment was done, including screening for comorbid conditions and treated as per the recommended guidelines. About two-thirds of the participants were aged 50 and above, of which more than half were illiterates, and 93.5% were living below the poverty line. Majority of ulcers were seen on the forefoot; with the head of meta-tarsal bone 27 (41.6%) as the commonest site, followed by calcaneum 23 (38.3%) and great toe 10 (16.6%). Mean ulcer depth was 0.61 (0.57) cm, the area was 5.24 (6.73) cm(2) and ulcer volume was 4.72 (14.33) cm(3). Ulcer dimensions were significantly associated with low body mass index, hypertension and smoking. CONCLUSIONS/SIGNIFICANCE: Identifying the risk factors delaying wound healing and detailed assessment of ulcers are of profound importance to predict the outcome of plantar ulcers in leprosy patients. The study findings indicate the need for better policies by the leprosy control program for the comprehensive management of plantar ulcers. Public Library of Science 2020-06-29 /pmc/articles/PMC7351235/ /pubmed/32598386 http://dx.doi.org/10.1371/journal.pntd.0008393 Text en © 2020 Upputuri et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Upputuri, Brahmaiah
Srikantam, Aparna
Mamidi, Raja Sriswan
Comorbidities associated with non- healing of plantar ulcers in leprosy patients
title Comorbidities associated with non- healing of plantar ulcers in leprosy patients
title_full Comorbidities associated with non- healing of plantar ulcers in leprosy patients
title_fullStr Comorbidities associated with non- healing of plantar ulcers in leprosy patients
title_full_unstemmed Comorbidities associated with non- healing of plantar ulcers in leprosy patients
title_short Comorbidities associated with non- healing of plantar ulcers in leprosy patients
title_sort comorbidities associated with non- healing of plantar ulcers in leprosy patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351235/
https://www.ncbi.nlm.nih.gov/pubmed/32598386
http://dx.doi.org/10.1371/journal.pntd.0008393
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