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Retinal detachment in retinitis pigmentosa

OBJECTIVE: Retinitis pigmentosa-related retinal detachment (RPRD) is rare, and the full spectrum of retinal complications is not well defined. To describe the types of retinal detachment in patients with retinitis pigmentosa and the surgical outcomes of RPRD. METHODS: This is a non-comparative, retr...

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Autores principales: Chan, Weng Onn, Brennan, Nicholas, Webster, Andrew R, Michaelides, Michel, Muqit, Mahiul M K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351280/
https://www.ncbi.nlm.nih.gov/pubmed/32671228
http://dx.doi.org/10.1136/bmjophth-2020-000454
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author Chan, Weng Onn
Brennan, Nicholas
Webster, Andrew R
Michaelides, Michel
Muqit, Mahiul M K
author_facet Chan, Weng Onn
Brennan, Nicholas
Webster, Andrew R
Michaelides, Michel
Muqit, Mahiul M K
author_sort Chan, Weng Onn
collection PubMed
description OBJECTIVE: Retinitis pigmentosa-related retinal detachment (RPRD) is rare, and the full spectrum of retinal complications is not well defined. To describe the types of retinal detachment in patients with retinitis pigmentosa and the surgical outcomes of RPRD. METHODS: This is a non-comparative, retrospective case series. An electronic database search was performed using Moorfields OpenEyes electronic health records. We identified 90 patients with RPRD between January 2000 and August 2017. Main outcome and measures are visual acuity (VA), surgical outcomes and classification of RPRD. RESULTS: Of the 90 patients/detachments, 61 (67.8%) were rhegmatogenous retinal detachment (RRD), 19 (21.1%) were exudative, 3 (3.3%) were tractional retinal detachment (TRD) and 7 (7.8%) had combined. 37.5% (9/24) of patients with exudative retinal detachment were treated with either cryotherapy or laser, and one patient underwent vitrectomy for vitreous haemorrhage. 56/90 patients underwent surgical intervention. Nine patients presented late and were deemed inoperable (two exudative and seven RRD). Of the RRD patients with full operative record, the primary attachment rate was 76.2% (16/21) and final reattachment rate was 85.7% (18/21) over a mean 15.4-year follow-up period. Mean VA for RRD surgery improved from 6/190 (1.51 logMAR) to 6/120 (1.31 logMAR) (p=0.194). In the TRD group, the mean VA was 6/300 (1.66 logMAR) at baseline and improved after surgery to 6/48 (0.90 logMAR) (p=0.421). CONCLUSIONS: We demonstrated a final reattachment rate of 85.7% with a trend toward better vision following intervention for patients with RPRD. However, the final long-term vision may be poor due to the natural progression of retinitis pigmentosa-associated macular degeneration.
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spelling pubmed-73512802020-07-14 Retinal detachment in retinitis pigmentosa Chan, Weng Onn Brennan, Nicholas Webster, Andrew R Michaelides, Michel Muqit, Mahiul M K BMJ Open Ophthalmol Original Research OBJECTIVE: Retinitis pigmentosa-related retinal detachment (RPRD) is rare, and the full spectrum of retinal complications is not well defined. To describe the types of retinal detachment in patients with retinitis pigmentosa and the surgical outcomes of RPRD. METHODS: This is a non-comparative, retrospective case series. An electronic database search was performed using Moorfields OpenEyes electronic health records. We identified 90 patients with RPRD between January 2000 and August 2017. Main outcome and measures are visual acuity (VA), surgical outcomes and classification of RPRD. RESULTS: Of the 90 patients/detachments, 61 (67.8%) were rhegmatogenous retinal detachment (RRD), 19 (21.1%) were exudative, 3 (3.3%) were tractional retinal detachment (TRD) and 7 (7.8%) had combined. 37.5% (9/24) of patients with exudative retinal detachment were treated with either cryotherapy or laser, and one patient underwent vitrectomy for vitreous haemorrhage. 56/90 patients underwent surgical intervention. Nine patients presented late and were deemed inoperable (two exudative and seven RRD). Of the RRD patients with full operative record, the primary attachment rate was 76.2% (16/21) and final reattachment rate was 85.7% (18/21) over a mean 15.4-year follow-up period. Mean VA for RRD surgery improved from 6/190 (1.51 logMAR) to 6/120 (1.31 logMAR) (p=0.194). In the TRD group, the mean VA was 6/300 (1.66 logMAR) at baseline and improved after surgery to 6/48 (0.90 logMAR) (p=0.421). CONCLUSIONS: We demonstrated a final reattachment rate of 85.7% with a trend toward better vision following intervention for patients with RPRD. However, the final long-term vision may be poor due to the natural progression of retinitis pigmentosa-associated macular degeneration. BMJ Publishing Group 2020-07-09 /pmc/articles/PMC7351280/ /pubmed/32671228 http://dx.doi.org/10.1136/bmjophth-2020-000454 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Original Research
Chan, Weng Onn
Brennan, Nicholas
Webster, Andrew R
Michaelides, Michel
Muqit, Mahiul M K
Retinal detachment in retinitis pigmentosa
title Retinal detachment in retinitis pigmentosa
title_full Retinal detachment in retinitis pigmentosa
title_fullStr Retinal detachment in retinitis pigmentosa
title_full_unstemmed Retinal detachment in retinitis pigmentosa
title_short Retinal detachment in retinitis pigmentosa
title_sort retinal detachment in retinitis pigmentosa
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351280/
https://www.ncbi.nlm.nih.gov/pubmed/32671228
http://dx.doi.org/10.1136/bmjophth-2020-000454
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