Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design

African horse sickness (AHS) is a devastating disease caused by African horse sickness virus (AHSV) and transmitted by arthropods between its equine hosts. AHSV is endemic in sub-Saharan Africa, where polyvalent live attenuated vaccine is in use even though it is associated with safety risks. This r...

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Autores principales: Calvo-Pinilla, Eva, Marín-López, Alejandro, Utrilla-Trigo, Sergio, Jiménez-Cabello, Luís, Ortego, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351391/
https://www.ncbi.nlm.nih.gov/pubmed/32659516
http://dx.doi.org/10.1016/j.coviro.2020.06.003
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author Calvo-Pinilla, Eva
Marín-López, Alejandro
Utrilla-Trigo, Sergio
Jiménez-Cabello, Luís
Ortego, Javier
author_facet Calvo-Pinilla, Eva
Marín-López, Alejandro
Utrilla-Trigo, Sergio
Jiménez-Cabello, Luís
Ortego, Javier
author_sort Calvo-Pinilla, Eva
collection PubMed
description African horse sickness (AHS) is a devastating disease caused by African horse sickness virus (AHSV) and transmitted by arthropods between its equine hosts. AHSV is endemic in sub-Saharan Africa, where polyvalent live attenuated vaccine is in use even though it is associated with safety risks. This review article summarizes and compares new strategies to generate safe and effective AHSV vaccines based on protein, virus like particles, viral vectors and reverse genetics technology. Manipulating the AHSV genome to generate synthetic viruses by means of reverse genetic systems has led to the generation of potential safe vaccine candidates that are under investigation.
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spelling pubmed-73513912020-07-13 Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design Calvo-Pinilla, Eva Marín-López, Alejandro Utrilla-Trigo, Sergio Jiménez-Cabello, Luís Ortego, Javier Curr Opin Virol Article African horse sickness (AHS) is a devastating disease caused by African horse sickness virus (AHSV) and transmitted by arthropods between its equine hosts. AHSV is endemic in sub-Saharan Africa, where polyvalent live attenuated vaccine is in use even though it is associated with safety risks. This review article summarizes and compares new strategies to generate safe and effective AHSV vaccines based on protein, virus like particles, viral vectors and reverse genetics technology. Manipulating the AHSV genome to generate synthetic viruses by means of reverse genetic systems has led to the generation of potential safe vaccine candidates that are under investigation. Elsevier B.V. 2020-10 2020-07-10 /pmc/articles/PMC7351391/ /pubmed/32659516 http://dx.doi.org/10.1016/j.coviro.2020.06.003 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Calvo-Pinilla, Eva
Marín-López, Alejandro
Utrilla-Trigo, Sergio
Jiménez-Cabello, Luís
Ortego, Javier
Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design
title Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design
title_full Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design
title_fullStr Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design
title_full_unstemmed Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design
title_short Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design
title_sort reverse genetics approaches: a novel strategy for african horse sickness virus vaccine design
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351391/
https://www.ncbi.nlm.nih.gov/pubmed/32659516
http://dx.doi.org/10.1016/j.coviro.2020.06.003
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