The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19...

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Autores principales: Pereira, Marcos, Paixão, Enny, Trajman, Anete, de Souza, Ramon Andrade, da Natividade, Marcio Santos, Pescarini, Julia M., Pereira, Susan Martins, Barreto, Florisneide Rodrigues, Ximenes, Ricardo, Dalcomo, Margareth, Ichihara, Maria Yury, Nunes, Ceuci, Barral-Netto, Manoel, Barreto, Maurício L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351640/
https://www.ncbi.nlm.nih.gov/pubmed/32653040
http://dx.doi.org/10.1186/s12931-020-01439-4
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author Pereira, Marcos
Paixão, Enny
Trajman, Anete
de Souza, Ramon Andrade
da Natividade, Marcio Santos
Pescarini, Julia M.
Pereira, Susan Martins
Barreto, Florisneide Rodrigues
Ximenes, Ricardo
Dalcomo, Margareth
Ichihara, Maria Yury
Nunes, Ceuci
Barral-Netto, Manoel
Barreto, Maurício L.
author_facet Pereira, Marcos
Paixão, Enny
Trajman, Anete
de Souza, Ramon Andrade
da Natividade, Marcio Santos
Pescarini, Julia M.
Pereira, Susan Martins
Barreto, Florisneide Rodrigues
Ximenes, Ricardo
Dalcomo, Margareth
Ichihara, Maria Yury
Nunes, Ceuci
Barral-Netto, Manoel
Barreto, Maurício L.
author_sort Pereira, Marcos
collection PubMed
description Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.
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spelling pubmed-73516402020-07-13 The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19 Pereira, Marcos Paixão, Enny Trajman, Anete de Souza, Ramon Andrade da Natividade, Marcio Santos Pescarini, Julia M. Pereira, Susan Martins Barreto, Florisneide Rodrigues Ximenes, Ricardo Dalcomo, Margareth Ichihara, Maria Yury Nunes, Ceuci Barral-Netto, Manoel Barreto, Maurício L. Respir Res Letter to the Editor Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings. BioMed Central 2020-07-11 2020 /pmc/articles/PMC7351640/ /pubmed/32653040 http://dx.doi.org/10.1186/s12931-020-01439-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Pereira, Marcos
Paixão, Enny
Trajman, Anete
de Souza, Ramon Andrade
da Natividade, Marcio Santos
Pescarini, Julia M.
Pereira, Susan Martins
Barreto, Florisneide Rodrigues
Ximenes, Ricardo
Dalcomo, Margareth
Ichihara, Maria Yury
Nunes, Ceuci
Barral-Netto, Manoel
Barreto, Maurício L.
The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_full The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_fullStr The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_full_unstemmed The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_short The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_sort need for fast-track, high-quality and low-cost studies about the role of the bcg vaccine in the fight against covid-19
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351640/
https://www.ncbi.nlm.nih.gov/pubmed/32653040
http://dx.doi.org/10.1186/s12931-020-01439-4
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