Design, synthesis, structure, in vitro cytotoxic activity evaluation and docking studies on target enzyme GSK-3β of new indirubin-3ʹ-oxime derivatives

The addition of chalcone and amine components into indirubin-3′-oxime resulted in 15 new derivatives with high yields. Structures of new derivatives were also elucidated through 1D, 2D-NMR and HR-MS(ESI) spectra and X-ray crystallography. All designed compounds were screened for cytotoxic activity a...

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Detalles Bibliográficos
Autores principales: Dan, Nguyen Trong, Quang, Hoang Duc, Van Truong, Vuong, Huu Nghi, Do, Cuong, Nguyen Manh, Cuong, To Dao, Toan, Tran Quoc, Bach, Long Giang, Anh, Nguyen Huu Thuan, Mai, Nguyen Thi, Lan, Ngo Thi, Van Chinh, Luu, Quan, Pham Minh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351726/
https://www.ncbi.nlm.nih.gov/pubmed/32651416
http://dx.doi.org/10.1038/s41598-020-68134-8

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