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Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation. As such, most human cancers differ from normal counterpart tissues by a plethora of energetic and metabolic reprogramming. Transcription factors of the MYC family are deregulated in up to 70% o...

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Detalles Bibliográficos
Autores principales: Dong, Yang, Tu, Rongfu, Liu, Hudan, Qing, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351732/
https://www.ncbi.nlm.nih.gov/pubmed/32651356
http://dx.doi.org/10.1038/s41392-020-00235-2
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author Dong, Yang
Tu, Rongfu
Liu, Hudan
Qing, Guoliang
author_facet Dong, Yang
Tu, Rongfu
Liu, Hudan
Qing, Guoliang
author_sort Dong, Yang
collection PubMed
description Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation. As such, most human cancers differ from normal counterpart tissues by a plethora of energetic and metabolic reprogramming. Transcription factors of the MYC family are deregulated in up to 70% of all human cancers through a variety of mechanisms. Oncogenic levels of MYC regulates almost every aspect of cellular metabolism, a recently revisited hallmark of cancer development. Meanwhile, unrestrained growth in response to oncogenic MYC expression creates dependency on MYC-driven metabolic pathways, which in principle provides novel targets for development of effective cancer therapeutics. In the current review, we summarize the significant progress made toward understanding how MYC deregulation fuels metabolic rewiring in malignant transformation.
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spelling pubmed-73517322020-07-13 Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat Dong, Yang Tu, Rongfu Liu, Hudan Qing, Guoliang Signal Transduct Target Ther Review Article Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation. As such, most human cancers differ from normal counterpart tissues by a plethora of energetic and metabolic reprogramming. Transcription factors of the MYC family are deregulated in up to 70% of all human cancers through a variety of mechanisms. Oncogenic levels of MYC regulates almost every aspect of cellular metabolism, a recently revisited hallmark of cancer development. Meanwhile, unrestrained growth in response to oncogenic MYC expression creates dependency on MYC-driven metabolic pathways, which in principle provides novel targets for development of effective cancer therapeutics. In the current review, we summarize the significant progress made toward understanding how MYC deregulation fuels metabolic rewiring in malignant transformation. Nature Publishing Group UK 2020-07-10 /pmc/articles/PMC7351732/ /pubmed/32651356 http://dx.doi.org/10.1038/s41392-020-00235-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Dong, Yang
Tu, Rongfu
Liu, Hudan
Qing, Guoliang
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
title Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
title_full Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
title_fullStr Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
title_full_unstemmed Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
title_short Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
title_sort regulation of cancer cell metabolism: oncogenic myc in the driver’s seat
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351732/
https://www.ncbi.nlm.nih.gov/pubmed/32651356
http://dx.doi.org/10.1038/s41392-020-00235-2
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