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Mnemonic prediction errors bias hippocampal states
When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351776/ https://www.ncbi.nlm.nih.gov/pubmed/32651370 http://dx.doi.org/10.1038/s41467-020-17287-1 |
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author | Bein, Oded Duncan, Katherine Davachi, Lila |
author_facet | Bein, Oded Duncan, Katherine Davachi, Lila |
author_sort | Bein, Oded |
collection | PubMed |
description | When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, as marked by distinct network connectivity between hippocampal subfields. During fMRI scanning, participants were cued to internally retrieve well-learned complex room-images and were then presented with either an identical or a modified image (0-4 changes). In the left hemisphere, we find that CA1-entorhinal connectivity increases, and CA1-CA3 connectivity decreases, with the number of changes. Further, in the left CA1, the similarity between activity patterns during cued-retrieval of the learned room and during the image is lower when the image includes changes, consistent with a prediction error signal in CA1. Our findings provide a mechanism by which mnemonic prediction errors may drive memory updating—by biasing hippocampal states. |
format | Online Article Text |
id | pubmed-7351776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73517762020-07-16 Mnemonic prediction errors bias hippocampal states Bein, Oded Duncan, Katherine Davachi, Lila Nat Commun Article When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, as marked by distinct network connectivity between hippocampal subfields. During fMRI scanning, participants were cued to internally retrieve well-learned complex room-images and were then presented with either an identical or a modified image (0-4 changes). In the left hemisphere, we find that CA1-entorhinal connectivity increases, and CA1-CA3 connectivity decreases, with the number of changes. Further, in the left CA1, the similarity between activity patterns during cued-retrieval of the learned room and during the image is lower when the image includes changes, consistent with a prediction error signal in CA1. Our findings provide a mechanism by which mnemonic prediction errors may drive memory updating—by biasing hippocampal states. Nature Publishing Group UK 2020-07-10 /pmc/articles/PMC7351776/ /pubmed/32651370 http://dx.doi.org/10.1038/s41467-020-17287-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bein, Oded Duncan, Katherine Davachi, Lila Mnemonic prediction errors bias hippocampal states |
title | Mnemonic prediction errors bias hippocampal states |
title_full | Mnemonic prediction errors bias hippocampal states |
title_fullStr | Mnemonic prediction errors bias hippocampal states |
title_full_unstemmed | Mnemonic prediction errors bias hippocampal states |
title_short | Mnemonic prediction errors bias hippocampal states |
title_sort | mnemonic prediction errors bias hippocampal states |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351776/ https://www.ncbi.nlm.nih.gov/pubmed/32651370 http://dx.doi.org/10.1038/s41467-020-17287-1 |
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