Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study

Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant d...

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Autores principales: Herting, Egbert, Kribs, Angela, Härtel, Christoph, von der Wense, Axel, Weller, Ursula, Hoehn, Thomas, Vochem, Matthias, Möller, Jens, Wieg, Christian, Roth, Bernhard, Göpel, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351829/
https://www.ncbi.nlm.nih.gov/pubmed/32067100
http://dx.doi.org/10.1007/s00431-020-03572-0
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author Herting, Egbert
Kribs, Angela
Härtel, Christoph
von der Wense, Axel
Weller, Ursula
Hoehn, Thomas
Vochem, Matthias
Möller, Jens
Wieg, Christian
Roth, Bernhard
Göpel, Wolfgang
author_facet Herting, Egbert
Kribs, Angela
Härtel, Christoph
von der Wense, Axel
Weller, Ursula
Hoehn, Thomas
Vochem, Matthias
Möller, Jens
Wieg, Christian
Roth, Bernhard
Göpel, Wolfgang
author_sort Herting, Egbert
collection PubMed
description Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.
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spelling pubmed-73518292020-07-14 Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study Herting, Egbert Kribs, Angela Härtel, Christoph von der Wense, Axel Weller, Ursula Hoehn, Thomas Vochem, Matthias Möller, Jens Wieg, Christian Roth, Bernhard Göpel, Wolfgang Eur J Pediatr Short Communication Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect. Springer Berlin Heidelberg 2020-02-18 2020 /pmc/articles/PMC7351829/ /pubmed/32067100 http://dx.doi.org/10.1007/s00431-020-03572-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Herting, Egbert
Kribs, Angela
Härtel, Christoph
von der Wense, Axel
Weller, Ursula
Hoehn, Thomas
Vochem, Matthias
Möller, Jens
Wieg, Christian
Roth, Bernhard
Göpel, Wolfgang
Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
title Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
title_full Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
title_fullStr Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
title_full_unstemmed Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
title_short Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
title_sort two-year outcome data suggest that less invasive surfactant administration (lisa) is safe. results from the follow-up of the randomized controlled amv (avoid mechanical ventilation) study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351829/
https://www.ncbi.nlm.nih.gov/pubmed/32067100
http://dx.doi.org/10.1007/s00431-020-03572-0
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