Cargando…

Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias

Aside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia...

Descripción completa

Detalles Bibliográficos
Autores principales: Hadjivassiliou, Marios, Graus, Francesc, Honnorat, Jerome, Jarius, Sven, Titulaer, Maarten, Manto, Mario, Hoggard, Nigel, Sarrigiannis, Ptolemaios, Mitoma, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351847/
https://www.ncbi.nlm.nih.gov/pubmed/32328884
http://dx.doi.org/10.1007/s12311-020-01132-8
_version_ 1783557527602987008
author Hadjivassiliou, Marios
Graus, Francesc
Honnorat, Jerome
Jarius, Sven
Titulaer, Maarten
Manto, Mario
Hoggard, Nigel
Sarrigiannis, Ptolemaios
Mitoma, Hiroshi
author_facet Hadjivassiliou, Marios
Graus, Francesc
Honnorat, Jerome
Jarius, Sven
Titulaer, Maarten
Manto, Mario
Hoggard, Nigel
Sarrigiannis, Ptolemaios
Mitoma, Hiroshi
author_sort Hadjivassiliou, Marios
collection PubMed
description Aside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia (PACA) is the term used to describe this later group. An International Task Force comprising experts in the field of immune ataxias was commissioned by the Society for Research on the Cerebellum and Ataxias (SRCA) in order to devise diagnostic criteria aiming to improve the diagnosis of PACA. The proposed diagnostic criteria for PACA are based on clinical (mode of onset, pattern of cerebellar involvement, presence of other autoimmune diseases), imaging findings (MRI and if available MR spectroscopy showing preferential, but not exclusive involvement of vermis) and laboratory investigations (CSF pleocytosis and/or CSF-restricted IgG oligoclonal bands) parameters. The aim is to enable clinicians to consider PACA when encountering a patient with progressive ataxia and no other diagnosis given that such consideration might have important therapeutic implications.
format Online
Article
Text
id pubmed-7351847
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-73518472020-07-14 Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias Hadjivassiliou, Marios Graus, Francesc Honnorat, Jerome Jarius, Sven Titulaer, Maarten Manto, Mario Hoggard, Nigel Sarrigiannis, Ptolemaios Mitoma, Hiroshi Cerebellum Consensus Paper Aside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia (PACA) is the term used to describe this later group. An International Task Force comprising experts in the field of immune ataxias was commissioned by the Society for Research on the Cerebellum and Ataxias (SRCA) in order to devise diagnostic criteria aiming to improve the diagnosis of PACA. The proposed diagnostic criteria for PACA are based on clinical (mode of onset, pattern of cerebellar involvement, presence of other autoimmune diseases), imaging findings (MRI and if available MR spectroscopy showing preferential, but not exclusive involvement of vermis) and laboratory investigations (CSF pleocytosis and/or CSF-restricted IgG oligoclonal bands) parameters. The aim is to enable clinicians to consider PACA when encountering a patient with progressive ataxia and no other diagnosis given that such consideration might have important therapeutic implications. Springer US 2020-04-23 2020 /pmc/articles/PMC7351847/ /pubmed/32328884 http://dx.doi.org/10.1007/s12311-020-01132-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Consensus Paper
Hadjivassiliou, Marios
Graus, Francesc
Honnorat, Jerome
Jarius, Sven
Titulaer, Maarten
Manto, Mario
Hoggard, Nigel
Sarrigiannis, Ptolemaios
Mitoma, Hiroshi
Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias
title Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias
title_full Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias
title_fullStr Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias
title_full_unstemmed Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias
title_short Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias
title_sort diagnostic criteria for primary autoimmune cerebellar ataxia—guidelines from an international task force on immune-mediated cerebellar ataxias
topic Consensus Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351847/
https://www.ncbi.nlm.nih.gov/pubmed/32328884
http://dx.doi.org/10.1007/s12311-020-01132-8
work_keys_str_mv AT hadjivassilioumarios diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT grausfrancesc diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT honnoratjerome diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT jariussven diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT titulaermaarten diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT mantomario diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT hoggardnigel diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT sarrigiannisptolemaios diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias
AT mitomahiroshi diagnosticcriteriaforprimaryautoimmunecerebellarataxiaguidelinesfromaninternationaltaskforceonimmunemediatedcerebellarataxias