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Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders

RATIONAL: The ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is assumed as a key factor regarding the development and maintenance of addictive behaviour. OBJECTIVES: While it is well known that stress is an important fac...

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Autores principales: Steins-Loeber, Sabine, Lörsch, Frank, van der Velde, Caroline, Müller, Astrid, Brand, Matthias, Duka, Theodora, Wolf, Oliver T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351872/
https://www.ncbi.nlm.nih.gov/pubmed/32506233
http://dx.doi.org/10.1007/s00213-020-05534-8
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author Steins-Loeber, Sabine
Lörsch, Frank
van der Velde, Caroline
Müller, Astrid
Brand, Matthias
Duka, Theodora
Wolf, Oliver T.
author_facet Steins-Loeber, Sabine
Lörsch, Frank
van der Velde, Caroline
Müller, Astrid
Brand, Matthias
Duka, Theodora
Wolf, Oliver T.
author_sort Steins-Loeber, Sabine
collection PubMed
description RATIONAL: The ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is assumed as a key factor regarding the development and maintenance of addictive behaviour. OBJECTIVES: While it is well known that stress is an important factor for relapse after treatment, little is known about the impact of stress on conditioned substance-associated stimuli and their influence on instrumental responding. METHODS: We administered in the present study a Pavlovian-to-instrumental transfer (PIT) paradigm with stimuli associated with smoking- and chocolate-related rewards using points in a token economy to light to moderate smokers who also indicated to like eating chocolate. After completion of the first two phases of the PIT paradigm (i.e. Pavlovian training and instrumental trainings), participants were randomly allocated to the socially evaluated cold pressor test or a control condition before the final phase of the PIT paradigm, the transfer phase, was administered. RESULTS: The presentation of a smoking-related stimulus enhanced instrumental responding for a smoking-related reward (i.e. ‘smoking-PIT’ effect) and presentation of a chocolate-related stimulus for a chocolate-related reward (i.e. ‘chocolate-PIT’ effect) in participants aware of the experimental contingencies as indicated by expectancy ratings. However, acute stress did not change (i.e. neither enhanced nor attenuated) the ‘smoking-PIT’ effect or the ‘chocolate-PIT’ effect, and no overall effect of acute stress on tobacco choice was observed in aware participants. CONCLUSIONS: The established role of stress in addiction appears not to be driven by an augmenting effect on the ability of drug stimuli to promote drug-seeking.
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spelling pubmed-73518722020-07-14 Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders Steins-Loeber, Sabine Lörsch, Frank van der Velde, Caroline Müller, Astrid Brand, Matthias Duka, Theodora Wolf, Oliver T. Psychopharmacology (Berl) Original Investigation RATIONAL: The ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is assumed as a key factor regarding the development and maintenance of addictive behaviour. OBJECTIVES: While it is well known that stress is an important factor for relapse after treatment, little is known about the impact of stress on conditioned substance-associated stimuli and their influence on instrumental responding. METHODS: We administered in the present study a Pavlovian-to-instrumental transfer (PIT) paradigm with stimuli associated with smoking- and chocolate-related rewards using points in a token economy to light to moderate smokers who also indicated to like eating chocolate. After completion of the first two phases of the PIT paradigm (i.e. Pavlovian training and instrumental trainings), participants were randomly allocated to the socially evaluated cold pressor test or a control condition before the final phase of the PIT paradigm, the transfer phase, was administered. RESULTS: The presentation of a smoking-related stimulus enhanced instrumental responding for a smoking-related reward (i.e. ‘smoking-PIT’ effect) and presentation of a chocolate-related stimulus for a chocolate-related reward (i.e. ‘chocolate-PIT’ effect) in participants aware of the experimental contingencies as indicated by expectancy ratings. However, acute stress did not change (i.e. neither enhanced nor attenuated) the ‘smoking-PIT’ effect or the ‘chocolate-PIT’ effect, and no overall effect of acute stress on tobacco choice was observed in aware participants. CONCLUSIONS: The established role of stress in addiction appears not to be driven by an augmenting effect on the ability of drug stimuli to promote drug-seeking. Springer Berlin Heidelberg 2020-06-06 2020 /pmc/articles/PMC7351872/ /pubmed/32506233 http://dx.doi.org/10.1007/s00213-020-05534-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Investigation
Steins-Loeber, Sabine
Lörsch, Frank
van der Velde, Caroline
Müller, Astrid
Brand, Matthias
Duka, Theodora
Wolf, Oliver T.
Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders
title Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders
title_full Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders
title_fullStr Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders
title_full_unstemmed Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders
title_short Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders
title_sort does acute stress influence the pavlovian-to-instrumental transfer effect? implications for substance use disorders
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351872/
https://www.ncbi.nlm.nih.gov/pubmed/32506233
http://dx.doi.org/10.1007/s00213-020-05534-8
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