Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

Despite their very close structural similarity, CxxC/S-type (class I) glutaredoxins (Grxs) act as oxidoreductases, while CGFS-type (class II) Grxs act as FeS cluster transferases. Here we show that the key determinant of Grx function is a distinct loop structure adjacent to the active site. Engineer...

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Detalles Bibliográficos
Autores principales: Trnka, Daniel, Engelke, Anna D., Gellert, Manuela, Moseler, Anna, Hossain, Md Faruq, Lindenberg, Tobias T., Pedroletti, Luca, Odermatt, Benjamin, de Souza, João V., Bronowska, Agnieszka K., Dick, Tobias P., Mühlenhoff, Uli, Meyer, Andreas J., Berndt, Carsten, Lillig, Christopher Horst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351949/
https://www.ncbi.nlm.nih.gov/pubmed/32651396
http://dx.doi.org/10.1038/s41467-020-17323-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351949/
https://www.ncbi.nlm.nih.gov/pubmed/32651396
http://dx.doi.org/10.1038/s41467-020-17323-0

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