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Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

DOCK (dedicator of cytokinesis) proteins are multidomain guanine nucleotide exchange factors (GEFs) for RHO GTPases that regulate intracellular actin dynamics. DOCK proteins share catalytic (DOCK(DHR2)) and membrane-associated (DOCK(DHR1)) domains. The structurally-related DOCK1 and DOCK2 GEFs are s...

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Detalles Bibliográficos
Autores principales:	Chang, Leifu, Yang, Jing, Jo, Chang Hwa, Boland, Andreas, Zhang, Ziguo, McLaughlin, Stephen H., Abu-Thuraia, Afnan, Killoran, Ryan C., Smith, Matthew J., Côté, Jean-Francois, Barford, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351999/ https://www.ncbi.nlm.nih.gov/pubmed/32651375 http://dx.doi.org/10.1038/s41467-020-17271-9

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