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No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis
BACKGROUND AND AIMS: There seems to be a higher risk of ischemic stroke and portal vein thrombosis in liver cirrhosis. Both of them may be associated with hypercoagulability. We aim to explore the association between ischemic stroke and portal vein thrombosis in liver cirrhosis. Study Design and Met...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352149/ https://www.ncbi.nlm.nih.gov/pubmed/32714987 http://dx.doi.org/10.1155/2020/8172673 |
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author | Zheng, Kexin Guo, Xiaozhong Yi, Fangfang Wang, Le Mancuso, Andrea Qi, Xingshun |
author_facet | Zheng, Kexin Guo, Xiaozhong Yi, Fangfang Wang, Le Mancuso, Andrea Qi, Xingshun |
author_sort | Zheng, Kexin |
collection | PubMed |
description | BACKGROUND AND AIMS: There seems to be a higher risk of ischemic stroke and portal vein thrombosis in liver cirrhosis. Both of them may be associated with hypercoagulability. We aim to explore the association between ischemic stroke and portal vein thrombosis in liver cirrhosis. Study Design and Methods. We selected patients from our prospectively established database of liver cirrhosis from December 2014 to July 2019. The difference between patients with and without stroke was compared. A 1 : 1 propensity score matching (PSM) analysis was performed to adjust the effect of age, sex, Child-Pugh score, and MELD score on our statistical results. RESULTS: There were 349 cirrhotic patients in the cross-sectional study. The prevalence of stroke, ischemic stroke, hemorrhagic stroke, and portal vein thrombosis was 8.88% (31/349), 8.31% (29/349), 1.15% (4/349), and 28.65% (100/349) in liver cirrhosis, respectively. Patients with ischemic stroke were significantly older and had significantly higher proportions of alcohol abuse, smoking, and arterial hypertension and higher levels of white blood cell and low-density lipoprotein. However, statistical analyses with and without PSM did not find any significant association between ischemic stroke and portal vein thrombosis in patients with liver cirrhosis. CONCLUSION: Ischemic stroke might not be associated with portal vein thrombosis in liver cirrhosis. |
format | Online Article Text |
id | pubmed-7352149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73521492020-07-25 No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis Zheng, Kexin Guo, Xiaozhong Yi, Fangfang Wang, Le Mancuso, Andrea Qi, Xingshun Biomed Res Int Research Article BACKGROUND AND AIMS: There seems to be a higher risk of ischemic stroke and portal vein thrombosis in liver cirrhosis. Both of them may be associated with hypercoagulability. We aim to explore the association between ischemic stroke and portal vein thrombosis in liver cirrhosis. Study Design and Methods. We selected patients from our prospectively established database of liver cirrhosis from December 2014 to July 2019. The difference between patients with and without stroke was compared. A 1 : 1 propensity score matching (PSM) analysis was performed to adjust the effect of age, sex, Child-Pugh score, and MELD score on our statistical results. RESULTS: There were 349 cirrhotic patients in the cross-sectional study. The prevalence of stroke, ischemic stroke, hemorrhagic stroke, and portal vein thrombosis was 8.88% (31/349), 8.31% (29/349), 1.15% (4/349), and 28.65% (100/349) in liver cirrhosis, respectively. Patients with ischemic stroke were significantly older and had significantly higher proportions of alcohol abuse, smoking, and arterial hypertension and higher levels of white blood cell and low-density lipoprotein. However, statistical analyses with and without PSM did not find any significant association between ischemic stroke and portal vein thrombosis in patients with liver cirrhosis. CONCLUSION: Ischemic stroke might not be associated with portal vein thrombosis in liver cirrhosis. Hindawi 2020-07-01 /pmc/articles/PMC7352149/ /pubmed/32714987 http://dx.doi.org/10.1155/2020/8172673 Text en Copyright © 2020 Kexin Zheng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zheng, Kexin Guo, Xiaozhong Yi, Fangfang Wang, Le Mancuso, Andrea Qi, Xingshun No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis |
title | No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis |
title_full | No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis |
title_fullStr | No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis |
title_full_unstemmed | No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis |
title_short | No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis |
title_sort | no association between ischemic stroke and portal vein thrombosis in liver cirrhosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352149/ https://www.ncbi.nlm.nih.gov/pubmed/32714987 http://dx.doi.org/10.1155/2020/8172673 |
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