Downregulation of PPARα during Experimental Left Ventricular Hypertrophy is Critically Dependent on Nox2 NADPH Oxidase Signalling

Pressure overload-induced left ventricular hypertrophy (LVH) is initially adaptive but ultimately promotes systolic dysfunction and chronic heart failure. Whilst underlying pathways are incompletely understood, increased reactive oxygen species generation from Nox2 NADPH oxidases, and metabolic remo...

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Detalles Bibliográficos
Autores principales: Harvey, Adam P., Robinson, Emma, Edgar, Kevin S., McMullan, Ross, O’Neill, Karla M., Alderdice, Matthew, Amirkhah, Raheleh, Dunne, Philip D., McDermott, Barbara J., Grieve, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352162/
https://www.ncbi.nlm.nih.gov/pubmed/32575797
http://dx.doi.org/10.3390/ijms21124406

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