Cargando…

An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling

Global identification of substrates for PTMs (post-translational modifications) represents a critical but yet dauntingly challenging task in understanding biology and disease pathology. Here we presented a synthetic biology approach, namely ‘YESS’, which coupled Y2H (yeast two hybrid) interactome sc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Chuanyin, Han, Tianting, Guo, Rong, Chen, Peng, Peng, Chao, Prag, Gali, Hu, Ronggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352202/ https://www.ncbi.nlm.nih.gov/pubmed/32545848 http://dx.doi.org/10.3390/ijms21124231

Ejemplares similares

Deletion of Ubiquitin Fold Modifier Protein Ufm1 Processing Peptidase Ufsp in L. donovani Abolishes Ufm1 Processing and Alters Pathogenesis
por: Gannavaram, Sreenivas, et al.
Publicado: (2014)

Highly Specialized Ubiquitin-Like Modifications: Shedding Light into the UFM1 Enigma
por: Witting, Katharina F., et al.
Publicado: (2021)

The Ufm1 Cascade
por: Daniel, Jens, et al.
Publicado: (2014)

Generation of the UFM1 Toolkit for Profiling UFM1‐Specific Proteases and Ligases
por: Witting, Katharina F., et al.
Publicado: (2018)

MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty
por: Li, Chuanyin, et al.
Publicado: (2021)

Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence
por: Padala, Prasanth, et al.
Publicado: (2017)

MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3
por: Li, Chuanyin, et al.
Publicado: (2020)

Decrypting UFMylation: How Proteins Are Modified with UFM1
por: Banerjee, Sayanika, et al.
Publicado: (2020)

Ubiquitin Engineering for Interrogating the Ubiquitin–Proteasome System and Novel Therapeutic Strategies
por: Tang, Jason Q., et al.
Publicado: (2023)

An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism
por: Chen, Changchun, et al.
Publicado: (2014)

MALDI-TOF Mass Spectrometry for interrogating ubiquitin enzymes
por: De Cesare, Virginia
Publicado: (2023)

Synthetic and semi-synthetic strategies to study ubiquitin signaling
por: van Tilburg, Gabriëlle BA, et al.
Publicado: (2016)

Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1 Protect Pancreatic Beta Cells from ER Stress-Induced Apoptosis
por: Lemaire, Katleen, et al.
Publicado: (2011)

Challenges and opportunities of integrating imaging and mathematical modelling to interrogate biological processes
por: Berg, Maxime, et al.
Publicado: (2022)

The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice
por: Tatsumi, Kanako, et al.
Publicado: (2011)

Structural basis for UFM1 transfer from UBA5 to UFC1
por: Kumar, Manoj, et al.
Publicado: (2021)

Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation
por: Millrine, David, et al.
Publicado: (2022)

Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice
por: Jiajia, Hu, et al.
Publicado: (2023)

Ufm1 inhibits LPS-induced endothelial cell inflammatory responses through the NF-κB signaling pathway
por: Li, Yuan-Yuan, et al.
Publicado: (2017)

UFM1 founder mutation in the Roma population causes recessive variant of H-ABC
por: Hamilton, Eline M.C., et al.
Publicado: (2017)

Characterization of Two Loss-of-Function NF1 Variants in Chinese Patients and Potential Molecular Interpretations of Phenotypes
por: Zhang, Tingting, et al.
Publicado: (2021)

Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling
por: Estrada, Javier, et al.
Publicado: (2016)

Interrogating cellular perception and decision making with optogenetic tools
por: Bugaj, Lukasz J., et al.
Publicado: (2017)

Down-regulated expression of CDK5RAP3 and UFM1 suggests a poor prognosis in gastric cancer patients
por: Lin, Mi, et al.
Publicado: (2022)

Cellular reagents for diagnostics and synthetic biology
por: Bhadra, Sanchita, et al.
Publicado: (2018)

Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications
por: Pratt, Matthew R., et al.
Publicado: (2015)

Development of multifunctional synthetic nucleosomes to interrogate chromatin-mediated protein interactions
por: Liu, Zheng, et al.
Publicado: (2023)

Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development
por: Nahorski, Michael S, et al.
Publicado: (2018)

The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I
por: Schuren, A.B.C., et al.
Publicado: (2021)

Modification of ERα by UFM1 Increases Its Stability and Transactivity for Breast Cancer Development
por: Yoo, Hee Min, et al.
Publicado: (2022)

The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
por: Ishimura, Ryosuke, et al.
Publicado: (2022)

Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
por: Chen, Sisi, et al.
Publicado: (2016)

Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules
por: Li, Kang, et al.
Publicado: (2018)

Evolutionary Interrogation of Human Biology in Well-Annotated Genomic Framework of Rhesus Macaque
por: Zhang, Shi-Jian, et al.
Publicado: (2014)

OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma
por: Reinke, Stacey N., et al.
Publicado: (2018)

Correction: UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling
por: Lin, Jian-Xian, et al.
Publicado: (2023)

Integrated genetic and pharmacologic interrogation of rare cancers
por: Hong, Andrew L., et al.
Publicado: (2016)

A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers
por: Ren, Jin, et al.
Publicado: (2021)

Corrigendum to: Modification of ERα by UFM1 Increases Its Stability and Transactivity for Breast Cancer Development
por: Yoo, Hee Min, et al.
Publicado: (2023)

Multiomics interrogation into HBV (Hepatitis B virus)-host interaction reveals novel coding potential in human genome, and identifies canonical and non-canonical proteins as host restriction factors against HBV
por: Yuan, Shilin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_csgaod6t4qtpr9b1u665pdu796