Cargando…

Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

The consequences of prostate cancer metastasis remain severe, with huge impact on the mortality and overall quality of life of affected patients. Despite the convoluted interplay and cross talk between various cell types and secreted factors in the metastatic process, cytokine and chemokines, along...

Descripción completa

Detalles Bibliográficos
Autores principales: Adekoya, Timothy O., Richardson, Ricardo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352203/
https://www.ncbi.nlm.nih.gov/pubmed/32585812
http://dx.doi.org/10.3390/ijms21124449
_version_ 1783557582827290624
author Adekoya, Timothy O.
Richardson, Ricardo M.
author_facet Adekoya, Timothy O.
Richardson, Ricardo M.
author_sort Adekoya, Timothy O.
collection PubMed
description The consequences of prostate cancer metastasis remain severe, with huge impact on the mortality and overall quality of life of affected patients. Despite the convoluted interplay and cross talk between various cell types and secreted factors in the metastatic process, cytokine and chemokines, along with their receptors and signaling axis, constitute important factors that help drive the sequence of events that lead to metastasis of prostate cancer. These proteins are involved in extracellular matrix remodeling, epithelial-mesenchymal-transition, angiogenesis, tumor invasion, premetastatic niche creation, extravasation, re-establishment of tumor cells in secondary organs as well as the remodeling of the metastatic tumor microenvironment. This review presents an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis. We also provide extensive description of their aberrant expression patterns in both advanced disease states and metastatic sites, as well as their functional involvement in the various stages of the prostate cancer metastatic process.
format Online
Article
Text
id pubmed-7352203
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73522032020-07-21 Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis Adekoya, Timothy O. Richardson, Ricardo M. Int J Mol Sci Review The consequences of prostate cancer metastasis remain severe, with huge impact on the mortality and overall quality of life of affected patients. Despite the convoluted interplay and cross talk between various cell types and secreted factors in the metastatic process, cytokine and chemokines, along with their receptors and signaling axis, constitute important factors that help drive the sequence of events that lead to metastasis of prostate cancer. These proteins are involved in extracellular matrix remodeling, epithelial-mesenchymal-transition, angiogenesis, tumor invasion, premetastatic niche creation, extravasation, re-establishment of tumor cells in secondary organs as well as the remodeling of the metastatic tumor microenvironment. This review presents an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis. We also provide extensive description of their aberrant expression patterns in both advanced disease states and metastatic sites, as well as their functional involvement in the various stages of the prostate cancer metastatic process. MDPI 2020-06-23 /pmc/articles/PMC7352203/ /pubmed/32585812 http://dx.doi.org/10.3390/ijms21124449 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Adekoya, Timothy O.
Richardson, Ricardo M.
Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis
title Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis
title_full Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis
title_fullStr Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis
title_full_unstemmed Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis
title_short Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis
title_sort cytokines and chemokines as mediators of prostate cancer metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352203/
https://www.ncbi.nlm.nih.gov/pubmed/32585812
http://dx.doi.org/10.3390/ijms21124449
work_keys_str_mv AT adekoyatimothyo cytokinesandchemokinesasmediatorsofprostatecancermetastasis
AT richardsonricardom cytokinesandchemokinesasmediatorsofprostatecancermetastasis