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Natural Metallic Nanoparticles for Application in Nano-Oncology
Here, the various types of naturally synthesized metallic nanoparticles, which are essentially composed of Ce, Ag, Au, Pt, Pd, Cu, Ni, Se, Fe, or their oxides, are presented, based on a literature analysis. The synthesis methods used to obtain them most often involve the reduction of metallic ions b...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352233/ https://www.ncbi.nlm.nih.gov/pubmed/32575884 http://dx.doi.org/10.3390/ijms21124412 |
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author | Alphandéry, Edouard |
author_facet | Alphandéry, Edouard |
author_sort | Alphandéry, Edouard |
collection | PubMed |
description | Here, the various types of naturally synthesized metallic nanoparticles, which are essentially composed of Ce, Ag, Au, Pt, Pd, Cu, Ni, Se, Fe, or their oxides, are presented, based on a literature analysis. The synthesis methods used to obtain them most often involve the reduction of metallic ions by biological materials or organisms, i.e., essentially plant extracts, yeasts, fungus, and bacteria. The anti-tumor activity of these nanoparticles has been demonstrated on different cancer lines. They rely on various mechanisms of action, such as heat, the release of chemotherapeutic drugs under a pH variation, nanoparticle excitation by radiation, or apoptotic tumor cell death. Among these natural metallic nanoparticles, one type, which consists of iron oxide nanoparticles produced by magnetotactic bacteria called magnetosomes, has been purified to remove endotoxins and abide by pharmacological regulations. It has been tested in vivo for anti-tumor efficacy. For that, purified and stabilized magnetosomes were injected in intracranial mouse glioblastoma tumors and repeatedly heated under the application of an alternating magnetic field, leading to the full disappearance of these tumors. As a whole, the results presented in the literature form a strong basis for pursuing the efforts towards the use of natural metallic nanoparticles for cancer treatment first pre-clinically and then clinically. |
format | Online Article Text |
id | pubmed-7352233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73522332020-07-21 Natural Metallic Nanoparticles for Application in Nano-Oncology Alphandéry, Edouard Int J Mol Sci Review Here, the various types of naturally synthesized metallic nanoparticles, which are essentially composed of Ce, Ag, Au, Pt, Pd, Cu, Ni, Se, Fe, or their oxides, are presented, based on a literature analysis. The synthesis methods used to obtain them most often involve the reduction of metallic ions by biological materials or organisms, i.e., essentially plant extracts, yeasts, fungus, and bacteria. The anti-tumor activity of these nanoparticles has been demonstrated on different cancer lines. They rely on various mechanisms of action, such as heat, the release of chemotherapeutic drugs under a pH variation, nanoparticle excitation by radiation, or apoptotic tumor cell death. Among these natural metallic nanoparticles, one type, which consists of iron oxide nanoparticles produced by magnetotactic bacteria called magnetosomes, has been purified to remove endotoxins and abide by pharmacological regulations. It has been tested in vivo for anti-tumor efficacy. For that, purified and stabilized magnetosomes were injected in intracranial mouse glioblastoma tumors and repeatedly heated under the application of an alternating magnetic field, leading to the full disappearance of these tumors. As a whole, the results presented in the literature form a strong basis for pursuing the efforts towards the use of natural metallic nanoparticles for cancer treatment first pre-clinically and then clinically. MDPI 2020-06-21 /pmc/articles/PMC7352233/ /pubmed/32575884 http://dx.doi.org/10.3390/ijms21124412 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alphandéry, Edouard Natural Metallic Nanoparticles for Application in Nano-Oncology |
title | Natural Metallic Nanoparticles for Application in Nano-Oncology |
title_full | Natural Metallic Nanoparticles for Application in Nano-Oncology |
title_fullStr | Natural Metallic Nanoparticles for Application in Nano-Oncology |
title_full_unstemmed | Natural Metallic Nanoparticles for Application in Nano-Oncology |
title_short | Natural Metallic Nanoparticles for Application in Nano-Oncology |
title_sort | natural metallic nanoparticles for application in nano-oncology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352233/ https://www.ncbi.nlm.nih.gov/pubmed/32575884 http://dx.doi.org/10.3390/ijms21124412 |
work_keys_str_mv | AT alphanderyedouard naturalmetallicnanoparticlesforapplicationinnanooncology |