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Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility

Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as gastroparesis. These disorders typically include debilitating symptoms, such as chronic nausea and vomiting. As no cures are currently available, clinical care is limited to symptom management, while the unde...

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Detalles Bibliográficos
Autores principales: Foong, Daphne, Zhou, Jerry, Zarrouk, Ali, Ho, Vincent, O’Connor, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352366/
https://www.ncbi.nlm.nih.gov/pubmed/32630607
http://dx.doi.org/10.3390/ijms21124540
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author Foong, Daphne
Zhou, Jerry
Zarrouk, Ali
Ho, Vincent
O’Connor, Michael D.
author_facet Foong, Daphne
Zhou, Jerry
Zarrouk, Ali
Ho, Vincent
O’Connor, Michael D.
author_sort Foong, Daphne
collection PubMed
description Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as gastroparesis. These disorders typically include debilitating symptoms, such as chronic nausea and vomiting. As no cures are currently available, clinical care is limited to symptom management, while the underlying causes of impaired GI motility remain unaddressed. The efficient movement of contents through the GI tract is facilitated by peristalsis. These rhythmic slow waves of GI muscle contraction are mediated by several cell types, including smooth muscle cells, enteric neurons, telocytes, and specialised gut pacemaker cells called interstitial cells of Cajal (ICC). As ICC dysfunction or loss has been implicated in several GI motility disorders, ICC represent a potentially valuable therapeutic target. Due to their availability, murine ICC have been extensively studied at the molecular level using both normal and diseased GI tissue. In contrast, relatively little is known about the biology of human ICC or their involvement in GI disease pathogenesis. Here, we demonstrate human gastric tissue as a source of primary human cells with ICC phenotype. Further characterisation of these cells will provide new insights into human GI biology, with the potential for developing novel therapies to address the fundamental causes of GI dysmotility.
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spelling pubmed-73523662020-07-15 Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility Foong, Daphne Zhou, Jerry Zarrouk, Ali Ho, Vincent O’Connor, Michael D. Int J Mol Sci Review Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as gastroparesis. These disorders typically include debilitating symptoms, such as chronic nausea and vomiting. As no cures are currently available, clinical care is limited to symptom management, while the underlying causes of impaired GI motility remain unaddressed. The efficient movement of contents through the GI tract is facilitated by peristalsis. These rhythmic slow waves of GI muscle contraction are mediated by several cell types, including smooth muscle cells, enteric neurons, telocytes, and specialised gut pacemaker cells called interstitial cells of Cajal (ICC). As ICC dysfunction or loss has been implicated in several GI motility disorders, ICC represent a potentially valuable therapeutic target. Due to their availability, murine ICC have been extensively studied at the molecular level using both normal and diseased GI tissue. In contrast, relatively little is known about the biology of human ICC or their involvement in GI disease pathogenesis. Here, we demonstrate human gastric tissue as a source of primary human cells with ICC phenotype. Further characterisation of these cells will provide new insights into human GI biology, with the potential for developing novel therapies to address the fundamental causes of GI dysmotility. MDPI 2020-06-25 /pmc/articles/PMC7352366/ /pubmed/32630607 http://dx.doi.org/10.3390/ijms21124540 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Foong, Daphne
Zhou, Jerry
Zarrouk, Ali
Ho, Vincent
O’Connor, Michael D.
Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility
title Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility
title_full Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility
title_fullStr Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility
title_full_unstemmed Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility
title_short Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility
title_sort understanding the biology of human interstitial cells of cajal in gastrointestinal motility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352366/
https://www.ncbi.nlm.nih.gov/pubmed/32630607
http://dx.doi.org/10.3390/ijms21124540
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