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Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance

Probiotics possibly affect local and systemic immune reactions and maintain the intestinal immune homeostasis in healthy individuals and patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 individuals (20 patients with IBS and 20 health...

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Autores principales: Velikova, Tsvetelina, Tumangelova-Yuzeir, Kalina, Georgieva, Ralitsa, Ivanova-Todorova, Ekaterina, Karaivanova, Elena, Nakov, Ventsislav, Nakov, Radislav, Kyurkchiev, Dobroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352398/
https://www.ncbi.nlm.nih.gov/pubmed/32517330
http://dx.doi.org/10.3390/nu12061706
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author Velikova, Tsvetelina
Tumangelova-Yuzeir, Kalina
Georgieva, Ralitsa
Ivanova-Todorova, Ekaterina
Karaivanova, Elena
Nakov, Ventsislav
Nakov, Radislav
Kyurkchiev, Dobroslav
author_facet Velikova, Tsvetelina
Tumangelova-Yuzeir, Kalina
Georgieva, Ralitsa
Ivanova-Todorova, Ekaterina
Karaivanova, Elena
Nakov, Ventsislav
Nakov, Radislav
Kyurkchiev, Dobroslav
author_sort Velikova, Tsvetelina
collection PubMed
description Probiotics possibly affect local and systemic immune reactions and maintain the intestinal immune homeostasis in healthy individuals and patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 individuals (20 patients with IBS and 20 healthy individuals) whose blood and fecal samples were collected before and after a 21-day administration of a product comprising Lactobacillus spp., larch arabinogalactan, and colostrum. The percentage of HLA-DR+ natural killer (NK) cells was higher in healthy individuals (p = 0.03) than in patients with IBS after product supplementation. In the fecal samples of patients with IBS, we observed a decline in IL-6, IFN-γ, TNF-α, and secretory IgA levels and, simultaneously, an increase in IL-10 and IL-17A levels after supplementation, although non-significant, whereas, in healthy individuals, we observed a significant decline in IL-6 and IFN-γ levels after supplementation (p < 0.001). Nevertheless, we observed a clinical improvement of symptoms in 65–75% of patients with IBS and the complete resolution of the initial symptoms in five of the 20 patients. We also observed a possible prophylactic effect by the inducing system antiviral impact accompanied by a trend for local immune tolerance in the gut in healthy individuals, where it is the desirable state.
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spelling pubmed-73523982020-07-15 Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance Velikova, Tsvetelina Tumangelova-Yuzeir, Kalina Georgieva, Ralitsa Ivanova-Todorova, Ekaterina Karaivanova, Elena Nakov, Ventsislav Nakov, Radislav Kyurkchiev, Dobroslav Nutrients Article Probiotics possibly affect local and systemic immune reactions and maintain the intestinal immune homeostasis in healthy individuals and patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 individuals (20 patients with IBS and 20 healthy individuals) whose blood and fecal samples were collected before and after a 21-day administration of a product comprising Lactobacillus spp., larch arabinogalactan, and colostrum. The percentage of HLA-DR+ natural killer (NK) cells was higher in healthy individuals (p = 0.03) than in patients with IBS after product supplementation. In the fecal samples of patients with IBS, we observed a decline in IL-6, IFN-γ, TNF-α, and secretory IgA levels and, simultaneously, an increase in IL-10 and IL-17A levels after supplementation, although non-significant, whereas, in healthy individuals, we observed a significant decline in IL-6 and IFN-γ levels after supplementation (p < 0.001). Nevertheless, we observed a clinical improvement of symptoms in 65–75% of patients with IBS and the complete resolution of the initial symptoms in five of the 20 patients. We also observed a possible prophylactic effect by the inducing system antiviral impact accompanied by a trend for local immune tolerance in the gut in healthy individuals, where it is the desirable state. MDPI 2020-06-07 /pmc/articles/PMC7352398/ /pubmed/32517330 http://dx.doi.org/10.3390/nu12061706 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Velikova, Tsvetelina
Tumangelova-Yuzeir, Kalina
Georgieva, Ralitsa
Ivanova-Todorova, Ekaterina
Karaivanova, Elena
Nakov, Ventsislav
Nakov, Radislav
Kyurkchiev, Dobroslav
Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance
title Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance
title_full Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance
title_fullStr Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance
title_full_unstemmed Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance
title_short Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance
title_sort lactobacilli supplemented with larch arabinogalactan and colostrum stimulates an immune response towards peripheral nk activation and gut tolerance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352398/
https://www.ncbi.nlm.nih.gov/pubmed/32517330
http://dx.doi.org/10.3390/nu12061706
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