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Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies
Despite numerous available resources of evidence, the results about the frequency of pregnancy-associated cancer (PAC) still show poor comparability due to dissimilarities in the study design and methodology, inclusion criteria, incoherent duration of follow-up and a heterogeneous reference populati...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352408/ https://www.ncbi.nlm.nih.gov/pubmed/32466494 http://dx.doi.org/10.3390/cancers12061356 |
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author | Dalmartello, Michela Negri, Eva La Vecchia, Carlo Scarfone, Giovanna Buonomo, Barbara Peccatori, Fedro A. Parazzini, Fabio |
author_facet | Dalmartello, Michela Negri, Eva La Vecchia, Carlo Scarfone, Giovanna Buonomo, Barbara Peccatori, Fedro A. Parazzini, Fabio |
author_sort | Dalmartello, Michela |
collection | PubMed |
description | Despite numerous available resources of evidence, the results about the frequency of pregnancy-associated cancer (PAC) still show poor comparability due to dissimilarities in the study design and methodology, inclusion criteria, incoherent duration of follow-up and a heterogeneous reference population. We conducted a systematic review of population-based studies on PAC published up to December 2019, to provide updated research on this topic, highlighting strengths and limitations. Of the 24 papers included, 11 considered all types of tumors and 13 dealt with specific types of cancer. Differences in the procedures for estimating the frequency of PAC emerged even among population studies. However, we found consistent results for overall frequency of PAC— around 1/1000 pregnancies. Our review suggests that about 25% of PAC cases are diagnosed during pregnancy, confirming the hypothesis of an excess of diagnosis in the postpregnancy period. Sparse and inconsistent results were found regarding a potential increase in the frequency of PAC over calendar years. Alignments in the strategy to identify PAC are needed to overcome methodological weaknesses. |
format | Online Article Text |
id | pubmed-7352408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73524082020-07-15 Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies Dalmartello, Michela Negri, Eva La Vecchia, Carlo Scarfone, Giovanna Buonomo, Barbara Peccatori, Fedro A. Parazzini, Fabio Cancers (Basel) Review Despite numerous available resources of evidence, the results about the frequency of pregnancy-associated cancer (PAC) still show poor comparability due to dissimilarities in the study design and methodology, inclusion criteria, incoherent duration of follow-up and a heterogeneous reference population. We conducted a systematic review of population-based studies on PAC published up to December 2019, to provide updated research on this topic, highlighting strengths and limitations. Of the 24 papers included, 11 considered all types of tumors and 13 dealt with specific types of cancer. Differences in the procedures for estimating the frequency of PAC emerged even among population studies. However, we found consistent results for overall frequency of PAC— around 1/1000 pregnancies. Our review suggests that about 25% of PAC cases are diagnosed during pregnancy, confirming the hypothesis of an excess of diagnosis in the postpregnancy period. Sparse and inconsistent results were found regarding a potential increase in the frequency of PAC over calendar years. Alignments in the strategy to identify PAC are needed to overcome methodological weaknesses. MDPI 2020-05-26 /pmc/articles/PMC7352408/ /pubmed/32466494 http://dx.doi.org/10.3390/cancers12061356 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dalmartello, Michela Negri, Eva La Vecchia, Carlo Scarfone, Giovanna Buonomo, Barbara Peccatori, Fedro A. Parazzini, Fabio Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies |
title | Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies |
title_full | Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies |
title_fullStr | Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies |
title_full_unstemmed | Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies |
title_short | Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies |
title_sort | frequency of pregnancy-associated cancer: a systematic review of population-based studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352408/ https://www.ncbi.nlm.nih.gov/pubmed/32466494 http://dx.doi.org/10.3390/cancers12061356 |
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