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Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies

Despite numerous available resources of evidence, the results about the frequency of pregnancy-associated cancer (PAC) still show poor comparability due to dissimilarities in the study design and methodology, inclusion criteria, incoherent duration of follow-up and a heterogeneous reference populati...

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Autores principales: Dalmartello, Michela, Negri, Eva, La Vecchia, Carlo, Scarfone, Giovanna, Buonomo, Barbara, Peccatori, Fedro A., Parazzini, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352408/
https://www.ncbi.nlm.nih.gov/pubmed/32466494
http://dx.doi.org/10.3390/cancers12061356
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author Dalmartello, Michela
Negri, Eva
La Vecchia, Carlo
Scarfone, Giovanna
Buonomo, Barbara
Peccatori, Fedro A.
Parazzini, Fabio
author_facet Dalmartello, Michela
Negri, Eva
La Vecchia, Carlo
Scarfone, Giovanna
Buonomo, Barbara
Peccatori, Fedro A.
Parazzini, Fabio
author_sort Dalmartello, Michela
collection PubMed
description Despite numerous available resources of evidence, the results about the frequency of pregnancy-associated cancer (PAC) still show poor comparability due to dissimilarities in the study design and methodology, inclusion criteria, incoherent duration of follow-up and a heterogeneous reference population. We conducted a systematic review of population-based studies on PAC published up to December 2019, to provide updated research on this topic, highlighting strengths and limitations. Of the 24 papers included, 11 considered all types of tumors and 13 dealt with specific types of cancer. Differences in the procedures for estimating the frequency of PAC emerged even among population studies. However, we found consistent results for overall frequency of PAC— around 1/1000 pregnancies. Our review suggests that about 25% of PAC cases are diagnosed during pregnancy, confirming the hypothesis of an excess of diagnosis in the postpregnancy period. Sparse and inconsistent results were found regarding a potential increase in the frequency of PAC over calendar years. Alignments in the strategy to identify PAC are needed to overcome methodological weaknesses.
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spelling pubmed-73524082020-07-15 Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies Dalmartello, Michela Negri, Eva La Vecchia, Carlo Scarfone, Giovanna Buonomo, Barbara Peccatori, Fedro A. Parazzini, Fabio Cancers (Basel) Review Despite numerous available resources of evidence, the results about the frequency of pregnancy-associated cancer (PAC) still show poor comparability due to dissimilarities in the study design and methodology, inclusion criteria, incoherent duration of follow-up and a heterogeneous reference population. We conducted a systematic review of population-based studies on PAC published up to December 2019, to provide updated research on this topic, highlighting strengths and limitations. Of the 24 papers included, 11 considered all types of tumors and 13 dealt with specific types of cancer. Differences in the procedures for estimating the frequency of PAC emerged even among population studies. However, we found consistent results for overall frequency of PAC— around 1/1000 pregnancies. Our review suggests that about 25% of PAC cases are diagnosed during pregnancy, confirming the hypothesis of an excess of diagnosis in the postpregnancy period. Sparse and inconsistent results were found regarding a potential increase in the frequency of PAC over calendar years. Alignments in the strategy to identify PAC are needed to overcome methodological weaknesses. MDPI 2020-05-26 /pmc/articles/PMC7352408/ /pubmed/32466494 http://dx.doi.org/10.3390/cancers12061356 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dalmartello, Michela
Negri, Eva
La Vecchia, Carlo
Scarfone, Giovanna
Buonomo, Barbara
Peccatori, Fedro A.
Parazzini, Fabio
Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies
title Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies
title_full Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies
title_fullStr Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies
title_full_unstemmed Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies
title_short Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies
title_sort frequency of pregnancy-associated cancer: a systematic review of population-based studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352408/
https://www.ncbi.nlm.nih.gov/pubmed/32466494
http://dx.doi.org/10.3390/cancers12061356
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