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Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism

We examined the association between high-density lipoprotein cholesterol (HDL-C), and exercise and vegetarian diets, in Taiwanese adults, based on the Methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism. Using regression models, we analyzed historical data collected from 9255 Taiwan B...

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Autores principales: Chang, Shu-Lin, Nfor, Oswald Ndi, Ho, Chien-Chang, Lee, Kuan-Jung, Lu, Wen-Yu, Lung, Chia-Chi, Tantoh, Disline Manli, Hsu, Shu-Yi, Chou, Ming-Chih, Liaw, Yung-Po
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352486/
https://www.ncbi.nlm.nih.gov/pubmed/32471241
http://dx.doi.org/10.3390/nu12061564
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author Chang, Shu-Lin
Nfor, Oswald Ndi
Ho, Chien-Chang
Lee, Kuan-Jung
Lu, Wen-Yu
Lung, Chia-Chi
Tantoh, Disline Manli
Hsu, Shu-Yi
Chou, Ming-Chih
Liaw, Yung-Po
author_facet Chang, Shu-Lin
Nfor, Oswald Ndi
Ho, Chien-Chang
Lee, Kuan-Jung
Lu, Wen-Yu
Lung, Chia-Chi
Tantoh, Disline Manli
Hsu, Shu-Yi
Chou, Ming-Chih
Liaw, Yung-Po
author_sort Chang, Shu-Lin
collection PubMed
description We examined the association between high-density lipoprotein cholesterol (HDL-C), and exercise and vegetarian diets, in Taiwanese adults, based on the Methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism. Using regression models, we analyzed historical data collected from 9255 Taiwan Biobank (TWB) participants from 2008 through 2015. Exposure to exercise was associated with higher HDL-C (β = 1.0508 and 1.4011 for GG and GA + AA individuals, respectively), whereas a vegetarian diet was associated with lower HDL-C (β = −6.2793 and −4.6359 for those with GG and GA + AA genotype, respectively). We found an interaction between exercise and diet among GG individuals (p = 0.0101). Compared with no exercise/no vegetarian diet, vegetarian diet/no exercise was associated with a 5.1514 mg/dl reduction in HDL-C among those with GG genotype (β = −5.1514, p < 0.0001) and a 4.8426 mg/dl reduction (β = −4.8426, p < 0.0001) among those with GA + AA genotype. Vegetarian diets in combination with exercise predicted a 6.5552 mg/dl reduction in HDL-C among GG individuals (β = −6.5552) and a 2.8668 mg/dl reduction among GA + AA individuals (p < 0.05). These findings demonstrated that vegetarian diet alone was associated with lower HDL-C, no matter the rs1801133 genotype. However, the inclusion of regular exercise predicted much lower levels among GG individuals, whereas levels among GA + AA individuals were relatively higher.
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spelling pubmed-73524862020-07-15 Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism Chang, Shu-Lin Nfor, Oswald Ndi Ho, Chien-Chang Lee, Kuan-Jung Lu, Wen-Yu Lung, Chia-Chi Tantoh, Disline Manli Hsu, Shu-Yi Chou, Ming-Chih Liaw, Yung-Po Nutrients Article We examined the association between high-density lipoprotein cholesterol (HDL-C), and exercise and vegetarian diets, in Taiwanese adults, based on the Methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism. Using regression models, we analyzed historical data collected from 9255 Taiwan Biobank (TWB) participants from 2008 through 2015. Exposure to exercise was associated with higher HDL-C (β = 1.0508 and 1.4011 for GG and GA + AA individuals, respectively), whereas a vegetarian diet was associated with lower HDL-C (β = −6.2793 and −4.6359 for those with GG and GA + AA genotype, respectively). We found an interaction between exercise and diet among GG individuals (p = 0.0101). Compared with no exercise/no vegetarian diet, vegetarian diet/no exercise was associated with a 5.1514 mg/dl reduction in HDL-C among those with GG genotype (β = −5.1514, p < 0.0001) and a 4.8426 mg/dl reduction (β = −4.8426, p < 0.0001) among those with GA + AA genotype. Vegetarian diets in combination with exercise predicted a 6.5552 mg/dl reduction in HDL-C among GG individuals (β = −6.5552) and a 2.8668 mg/dl reduction among GA + AA individuals (p < 0.05). These findings demonstrated that vegetarian diet alone was associated with lower HDL-C, no matter the rs1801133 genotype. However, the inclusion of regular exercise predicted much lower levels among GG individuals, whereas levels among GA + AA individuals were relatively higher. MDPI 2020-05-27 /pmc/articles/PMC7352486/ /pubmed/32471241 http://dx.doi.org/10.3390/nu12061564 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Shu-Lin
Nfor, Oswald Ndi
Ho, Chien-Chang
Lee, Kuan-Jung
Lu, Wen-Yu
Lung, Chia-Chi
Tantoh, Disline Manli
Hsu, Shu-Yi
Chou, Ming-Chih
Liaw, Yung-Po
Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism
title Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism
title_full Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism
title_fullStr Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism
title_full_unstemmed Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism
title_short Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism
title_sort combination of exercise and vegetarian diet: relationship with high density-lipoprotein cholesterol in taiwanese adults based on mthfr rs1801133 polymorphism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352486/
https://www.ncbi.nlm.nih.gov/pubmed/32471241
http://dx.doi.org/10.3390/nu12061564
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