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Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy

In recent years, immunotherapy has become the most promising therapy for a variety of cancer types. The development of immune checkpoint blockade (ICB) therapies, the adoptive transfer of tumor-specific T cells (adoptive cell therapy (ACT)) or the generation of T cells engineered with chimeric antig...

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Autores principales: Ginefra, Pierpaolo, Lorusso, Girieca, Vannini, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352556/
https://www.ncbi.nlm.nih.gov/pubmed/32580431
http://dx.doi.org/10.3390/ijms21124441
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author Ginefra, Pierpaolo
Lorusso, Girieca
Vannini, Nicola
author_facet Ginefra, Pierpaolo
Lorusso, Girieca
Vannini, Nicola
author_sort Ginefra, Pierpaolo
collection PubMed
description In recent years, immunotherapy has become the most promising therapy for a variety of cancer types. The development of immune checkpoint blockade (ICB) therapies, the adoptive transfer of tumor-specific T cells (adoptive cell therapy (ACT)) or the generation of T cells engineered with chimeric antigen receptors (CAR) have been successfully applied to elicit durable immunological responses in cancer patients. However, not all the patients respond to these therapies, leaving a consistent gap of therapeutic improvement that still needs to be filled. The innate immune components of the tumor microenvironment play a pivotal role in the activation and modulation of the adaptive immune response against the tumor. Indeed, several efforts are made to develop strategies aimed to harness innate immune cells in the context of cancer immunotherapy. In this review, we describe the contribution of innate immune cells in T-cell-based cancer immunotherapy and the therapeutic approaches implemented to broaden the efficacy of these therapies in cancer patients.
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spelling pubmed-73525562020-07-15 Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy Ginefra, Pierpaolo Lorusso, Girieca Vannini, Nicola Int J Mol Sci Review In recent years, immunotherapy has become the most promising therapy for a variety of cancer types. The development of immune checkpoint blockade (ICB) therapies, the adoptive transfer of tumor-specific T cells (adoptive cell therapy (ACT)) or the generation of T cells engineered with chimeric antigen receptors (CAR) have been successfully applied to elicit durable immunological responses in cancer patients. However, not all the patients respond to these therapies, leaving a consistent gap of therapeutic improvement that still needs to be filled. The innate immune components of the tumor microenvironment play a pivotal role in the activation and modulation of the adaptive immune response against the tumor. Indeed, several efforts are made to develop strategies aimed to harness innate immune cells in the context of cancer immunotherapy. In this review, we describe the contribution of innate immune cells in T-cell-based cancer immunotherapy and the therapeutic approaches implemented to broaden the efficacy of these therapies in cancer patients. MDPI 2020-06-22 /pmc/articles/PMC7352556/ /pubmed/32580431 http://dx.doi.org/10.3390/ijms21124441 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ginefra, Pierpaolo
Lorusso, Girieca
Vannini, Nicola
Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy
title Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy
title_full Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy
title_fullStr Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy
title_full_unstemmed Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy
title_short Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy
title_sort innate immune cells and their contribution to t-cell-based immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352556/
https://www.ncbi.nlm.nih.gov/pubmed/32580431
http://dx.doi.org/10.3390/ijms21124441
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