Cargando…

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats

The downregulation of uncoupling protein-2 (UCP2) is associated with increased brain and kidney injury in stroke-prone spontaneously hypertensive rats (SHRSP) fed with a Japanese style hypersodic diet (JD). Systemic overexpression of UCP2 reduces organ damage in JD-fed SHRSP. We examined the effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Busceti, Carla L., Cotugno, Maria, Bianchi, Franca, Forte, Maurizio, Stanzione, Rosita, Marchitti, Simona, Battaglia, Giuseppe, Nicoletti, Ferdinando, Fornai, Francesco, Rubattu, Speranza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352594/ https://www.ncbi.nlm.nih.gov/pubmed/32560241 http://dx.doi.org/10.3390/ijms21124289

Ejemplares similares

Uncoupling Protein 2 as a Pathogenic Determinant and Therapeutic Target in Cardiovascular and Metabolic Diseases
por: Stanzione, Rosita, et al.
Publicado: (2022)

A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat
por: Stanzione, Rosita, et al.
Publicado: (2017)

Role of Uncoupling Protein 2 Gene Polymorphisms on the Risk of Ischemic Stroke in a Sardinian Population
por: Stanzione, Rosita, et al.
Publicado: (2022)

Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains
por: Rubattu, Speranza, et al.
Publicado: (2015)

Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms
por: Stanzione, Rosita, et al.
Publicado: (2020)

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat
por: Rubattu, Speranza, et al.
Publicado: (2017)

Beneficial Effects of Citrus Bergamia Polyphenolic Fraction on Saline Load-Induced Injury in Primary Cerebral Endothelial Cells from the Stroke-Prone Spontaneously Hypertensive Rat Model
por: Stanzione, Rosita, et al.
Publicado: (2023)

An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation
por: Forte, Maurizio, et al.
Publicado: (2021)

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway
por: Busceti, Carla L., et al.
Publicado: (2017)

Impact of a NDUFC2 Variant on the Occurrence of Acute Coronary Syndromes
por: Gallo, Giovanna, et al.
Publicado: (2022)

Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation
por: Gallo, Giovanna, et al.
Publicado: (2020)

Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
por: Pierelli, Giorgia, et al.
Publicado: (2017)

The C2238/αANP Variant Is a Negative Modulator of Both Viability and Function of Coronary Artery Smooth Muscle Cells
por: Rubattu, Speranza, et al.
Publicado: (2014)

Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension
por: Gallo, Giovanna, et al.
Publicado: (2023)

Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage
por: Pepe, Giuseppe, et al.
Publicado: (2021)

Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure
por: Raffa, Salvatore, et al.
Publicado: (2023)

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease
por: Rubattu, Speranza, et al.
Publicado: (2016)

The T2238C Human Atrial Natriuretic Peptide Molecular Variant and the Risk of Cardiovascular Diseases
por: Rubattu, Speranza, et al.
Publicado: (2018)

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro
por: Stanzione, R, et al.
Publicado: (2015)

Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor
por: Busceti, Carla Letizia, et al.
Publicado: (2018)

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease
por: Rubattu, Speranza, et al.
Publicado: (2016)

Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage Development
por: Rubattu, Speranza, et al.
Publicado: (2019)

Natriuretic Peptides, Cognitive Impairment and Dementia: An Intriguing Pathogenic Link with Implications in Hypertension
por: Gallo, Giovanna, et al.
Publicado: (2020)

Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia
por: Nikanorova, Alena A., et al.
Publicado: (2022)

New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis
por: Robbins, Delira, et al.
Publicado: (2011)

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
por: Pravednikova, Anna E., et al.
Publicado: (2020)

Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
por: Gagelin, Antoine, et al.
Publicado: (2023)

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease
por: Huesca-Gómez, Claudia, et al.
Publicado: (2023)

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage
por: Gómez-Hernández, Almudena, et al.
Publicado: (2014)

Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate
por: Lunetti, Paola, et al.
Publicado: (2022)

Atrial Natriuretic Peptide Single Nucleotide Polymorphisms in Patients with Nonfamilial Structural Atrial Fibrillation
por: Francia, Pietro, et al.
Publicado: (2013)

Unveiling the Role of the Proton Gateway, Uncoupling Proteins (UCPs), in Cancer Cachexia
por: Joshi, Mit, et al.
Publicado: (2023)

Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity
por: Kukat, Alexandra, et al.
Publicado: (2014)

Inhibition of miR‐155 Attenuates Detrimental Vascular Effects of Tobacco Cigarette Smoking
por: Frati, Giacomo, et al.
Publicado: (2020)

C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP
por: Carnevale, Roberto, et al.
Publicado: (2017)

Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP(+) Toxicity in Neuronal Cells
por: Ho, Philip Wing-Lok, et al.
Publicado: (2009)

Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation
por: Hermes, Gretchen, et al.
Publicado: (2016)

In the Early Stages of Diabetes, Rat Retinal Mitochondria Undergo Mild Uncoupling due to UCP2 Activity
por: Osorio-Paz, Ixchel, et al.
Publicado: (2015)

Correlation Between Pancreatic Islet Uncoupling Protein-2 (UCP2) mRNA Concentration And Insulin Status in Rats
por: Kassis, Nadim, et al.
Publicado: (2000)

Analysis of Uncoupling Protein 2-Deficient Mice upon Anaesthesia and Sedation Revealed a Role for UCP2 in Locomotion
por: Alves-Guerra, Marie-Clotilde, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2ptfnaqjoo5jppeg745181p8ha