Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study

Dysregulation of fatty acid oxidation and accumulation of fatty acids can cause kidney injury. Nifedipine modulates lipogenesis-related transcriptional factor SREBP-1/2 in proximal tubular cells by inhibiting the Adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) pathway in vitro. Howe...

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Detalles Bibliográficos
Autores principales: Lin, Yen-Chung, Wang, Jhih-Cheng, Wu, Mai-Szu, Lin, Yuh-Feng, Chen, Chang-Rong, Chen, Chang-Yu, Chen, Kuan-Chou, Peng, Chiung-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352626/
https://www.ncbi.nlm.nih.gov/pubmed/32575412
http://dx.doi.org/10.3390/ijms21124359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352626/
https://www.ncbi.nlm.nih.gov/pubmed/32575412
http://dx.doi.org/10.3390/ijms21124359

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