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Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma

Extensive desmoplastic stroma is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and contributes to tumor progression and to the relative resistance of tumor cells towards (radio) chemotherapy. Thus, therapies that target the stroma are under intense investigation. To allow the stratification...

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Autores principales: Mayer, Philipp, Jiang, Yixin, Kuder, Tristan A., Bergmann, Frank, Khristenko, Ekaterina, Steinle, Verena, Kaiser, Jörg, Hackert, Thilo, Kauczor, Hans-Ulrich, Klauß, Miriam, Gaida, Matthias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352692/
https://www.ncbi.nlm.nih.gov/pubmed/32580519
http://dx.doi.org/10.3390/cancers12061656
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author Mayer, Philipp
Jiang, Yixin
Kuder, Tristan A.
Bergmann, Frank
Khristenko, Ekaterina
Steinle, Verena
Kaiser, Jörg
Hackert, Thilo
Kauczor, Hans-Ulrich
Klauß, Miriam
Gaida, Matthias M.
author_facet Mayer, Philipp
Jiang, Yixin
Kuder, Tristan A.
Bergmann, Frank
Khristenko, Ekaterina
Steinle, Verena
Kaiser, Jörg
Hackert, Thilo
Kauczor, Hans-Ulrich
Klauß, Miriam
Gaida, Matthias M.
author_sort Mayer, Philipp
collection PubMed
description Extensive desmoplastic stroma is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and contributes to tumor progression and to the relative resistance of tumor cells towards (radio) chemotherapy. Thus, therapies that target the stroma are under intense investigation. To allow the stratification of patients who would profit from such therapies, non-invasive methods assessing the stroma content in relation to tumor mass are required. In the current prospective study, we investigated the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI), a radiologic method that measures the random motion of water molecules in tissue, in the assessment of PDAC lesions, and more specifically in the desmoplastic tumor stroma. We made use of a sophisticated DW-MRI approach, the so-called diffusion kurtosis imaging (DKI), which possesses potential advantages over conventional and widely used monoexponential diffusion-weighted imaging analysis (cDWI). We found that the diffusion constant D from DKI is highly negatively correlated with the percentage of tumor stroma, the latter determined by histology. D performed significantly better than the widely used apparent diffusion coefficient (ADC) from cDWI in distinguishing stroma-rich (>50% stroma percentage) from stroma-poor tumors (≤50% stroma percentage). Moreover, we could prove the potential of the diffusion constant D as a clinically useful imaging parameter for the differentiation of PDAC-lesions from non-neoplastic pancreatic parenchyma. Therefore, the diffusion constant D from DKI could represent a valuable non-invasive imaging biomarker for assessment of stroma content in PDAC, which is applicable for the clinical diagnostic of PDAC.
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spelling pubmed-73526922020-07-21 Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma Mayer, Philipp Jiang, Yixin Kuder, Tristan A. Bergmann, Frank Khristenko, Ekaterina Steinle, Verena Kaiser, Jörg Hackert, Thilo Kauczor, Hans-Ulrich Klauß, Miriam Gaida, Matthias M. Cancers (Basel) Article Extensive desmoplastic stroma is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and contributes to tumor progression and to the relative resistance of tumor cells towards (radio) chemotherapy. Thus, therapies that target the stroma are under intense investigation. To allow the stratification of patients who would profit from such therapies, non-invasive methods assessing the stroma content in relation to tumor mass are required. In the current prospective study, we investigated the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI), a radiologic method that measures the random motion of water molecules in tissue, in the assessment of PDAC lesions, and more specifically in the desmoplastic tumor stroma. We made use of a sophisticated DW-MRI approach, the so-called diffusion kurtosis imaging (DKI), which possesses potential advantages over conventional and widely used monoexponential diffusion-weighted imaging analysis (cDWI). We found that the diffusion constant D from DKI is highly negatively correlated with the percentage of tumor stroma, the latter determined by histology. D performed significantly better than the widely used apparent diffusion coefficient (ADC) from cDWI in distinguishing stroma-rich (>50% stroma percentage) from stroma-poor tumors (≤50% stroma percentage). Moreover, we could prove the potential of the diffusion constant D as a clinically useful imaging parameter for the differentiation of PDAC-lesions from non-neoplastic pancreatic parenchyma. Therefore, the diffusion constant D from DKI could represent a valuable non-invasive imaging biomarker for assessment of stroma content in PDAC, which is applicable for the clinical diagnostic of PDAC. MDPI 2020-06-22 /pmc/articles/PMC7352692/ /pubmed/32580519 http://dx.doi.org/10.3390/cancers12061656 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mayer, Philipp
Jiang, Yixin
Kuder, Tristan A.
Bergmann, Frank
Khristenko, Ekaterina
Steinle, Verena
Kaiser, Jörg
Hackert, Thilo
Kauczor, Hans-Ulrich
Klauß, Miriam
Gaida, Matthias M.
Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma
title Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma
title_full Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma
title_fullStr Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma
title_full_unstemmed Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma
title_short Diffusion Kurtosis Imaging—A Superior Approach to Assess Tumor–Stroma Ratio in Pancreatic Ductal Adenocarcinoma
title_sort diffusion kurtosis imaging—a superior approach to assess tumor–stroma ratio in pancreatic ductal adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352692/
https://www.ncbi.nlm.nih.gov/pubmed/32580519
http://dx.doi.org/10.3390/cancers12061656
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