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Radiation Dose Escalation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma

We previously reported that a combination of 10 Gy of X-ray irradiation and dual immune checkpoint blockade with anti-CTLA-4 (C4) and anti-PD-L1 antibodies produced a significant shrinkage of irradiated and unirradiated tumors (abscopal effect) and prolonged overall survival. However, the optimal ra...

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Detalles Bibliográficos
Autores principales: Takenaka, Wataru, Takahashi, Yutaka, Tamari, Keisuke, Minami, Kazumasa, Katsuki, Shohei, Seo, Yuji, Isohashi, Fumiaki, Koizumi, Masahiko, Ogawa, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352693/
https://www.ncbi.nlm.nih.gov/pubmed/32545427
http://dx.doi.org/10.3390/cancers12061546

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