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Radiation Dose Escalation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma
We previously reported that a combination of 10 Gy of X-ray irradiation and dual immune checkpoint blockade with anti-CTLA-4 (C4) and anti-PD-L1 antibodies produced a significant shrinkage of irradiated and unirradiated tumors (abscopal effect) and prolonged overall survival. However, the optimal ra...
Autores principales: | Takenaka, Wataru, Takahashi, Yutaka, Tamari, Keisuke, Minami, Kazumasa, Katsuki, Shohei, Seo, Yuji, Isohashi, Fumiaki, Koizumi, Masahiko, Ogawa, Kazuhiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352693/ https://www.ncbi.nlm.nih.gov/pubmed/32545427 http://dx.doi.org/10.3390/cancers12061546 |
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