An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells

Background: Upregulation of anti-apoptotic Bcl-2 proteins in advanced prostate cancer leads to therapeutic resistance by prevention of cell death. New therapeutic approaches aim to target the Bcl-2 proteins for the restoration of apoptosis. Methods: The immunotoxin hD7-1(VL-VH)-PE40 specifically bin...

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Detalles Bibliográficos
Autores principales: Masilamani, Anie P., Dettmer-Monaco, Viviane, Monaco, Gianni, Cathomen, Toni, Kuckuck, Irina, Schultze-Seemann, Susanne, Huber, Nathalie, Wolf, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352695/
https://www.ncbi.nlm.nih.gov/pubmed/32580291
http://dx.doi.org/10.3390/cancers12061648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352695/
https://www.ncbi.nlm.nih.gov/pubmed/32580291
http://dx.doi.org/10.3390/cancers12061648

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