Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns

Cancer cells activate a telomere maintenance mechanism like telomerase in order to proliferate indefinitely. Telomerase can be reactivated by gain-of-function Telomerase Reverse Transcriptase (TERT) promoter mutations (TPMs) that occur in several cancer subtypes with high incidence and association w...

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Detalles Bibliográficos
Autores principales: Posch, Alexandra, Hofer-Zeni, Sarah, Klieser, Eckhard, Primavesi, Florian, Naderlinger, Elisabeth, Brandstetter, Anita, Filipits, Martin, Urbas, Romana, Swiercynski, Stefan, Jäger, Tarkan, Winkelmann, Paul, Kiesslich, Tobias, Lu, Lingeng, Neureiter, Daniel, Stättner, Stefan, Holzmann, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352723/
https://www.ncbi.nlm.nih.gov/pubmed/32575418
http://dx.doi.org/10.3390/cancers12061625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352723/
https://www.ncbi.nlm.nih.gov/pubmed/32575418
http://dx.doi.org/10.3390/cancers12061625

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