Cargando…

Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns

Cancer cells activate a telomere maintenance mechanism like telomerase in order to proliferate indefinitely. Telomerase can be reactivated by gain-of-function Telomerase Reverse Transcriptase (TERT) promoter mutations (TPMs) that occur in several cancer subtypes with high incidence and association w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Posch, Alexandra, Hofer-Zeni, Sarah, Klieser, Eckhard, Primavesi, Florian, Naderlinger, Elisabeth, Brandstetter, Anita, Filipits, Martin, Urbas, Romana, Swiercynski, Stefan, Jäger, Tarkan, Winkelmann, Paul, Kiesslich, Tobias, Lu, Lingeng, Neureiter, Daniel, Stättner, Stefan, Holzmann, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352723/ https://www.ncbi.nlm.nih.gov/pubmed/32575418 http://dx.doi.org/10.3390/cancers12061625

Ejemplares similares

Thermographic real-time-monitoring of surgical radiofrequency and microwave ablation in a perfused porcine liver model
por: Primavesi, Florian, et al.
Publicado: (2018)

HDAC-Linked “Proliferative” miRNA Expression Pattern in Pancreatic Neuroendocrine Tumors
por: Klieser, Eckhard, et al.
Publicado: (2018)

Pancreatic cancer in young adults: changes, challenges, and solutions
por: Primavesi, Florian, et al.
Publicado: (2019)

Feasibility of Kahoot! as a Real-Time Assessment Tool in (Histo-)pathology Classroom Teaching
por: Neureiter, Daniel, et al.
Publicado: (2020)

Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients
por: Urbas, Romana, et al.
Publicado: (2016)

The potential predictive value of tumor budding for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer
por: Jäger, Tarkan, et al.
Publicado: (2018)

Robust linear regression model of Ki-67 for mitotic rate in gastrointestinal stromal tumors
por: KEMMERLING, RALF, et al.
Publicado: (2014)

GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?
por: Illig, Romana, et al.
Publicado: (2013)

HDAC Screening Identifies the HDAC Class I Inhibitor Romidepsin as a Promising Epigenetic Drug for Biliary Tract Cancer
por: Mayr, Christian, et al.
Publicado: (2021)

Systematic Review on Optical Diagnosis of Early Gastrointestinal Neoplasia
por: Wagner, Andrej, et al.
Publicado: (2021)

Pharmacological Inhibition of Class IIA HDACs by LMK-235 in Pancreatic Neuroendocrine Tumor Cells
por: Wanek, Julia, et al.
Publicado: (2018)

The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications
por: Klieser, Eckhard, et al.
Publicado: (2019)

A Preoperative Clinical Risk Score Including C-Reactive Protein Predicts Histological Tumor Characteristics and Patient Survival after Surgery for Sporadic Non-Functional Pancreatic Neuroendocrine Neoplasms: An International Multicenter Cohort Study †
por: Primavesi, Florian, et al.
Publicado: (2020)

Expression of the microRNA-200 Family, microRNA-205, and Markers of Epithelial–Mesenchymal Transition as Predictors for Endoscopic Submucosal Dissection over Esophagectomy in Esophageal Adenocarcinoma: A Single-Center Experience
por: Neureiter, Daniel, et al.
Publicado: (2020)

How We Treat Localized Rectal Cancer—An Institutional Paradigm for Total Neoadjuvant Therapy
por: Roeder, Falk, et al.
Publicado: (2022)

Progressive Oncological Surgery Is Associated with Increased Curative Resection Rates and Improved Survival in Metastatic Colorectal Cancer
por: Primavesi, Florian, et al.
Publicado: (2019)

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas
por: Naderlinger, Elisabeth, et al.
Publicado: (2017)

Systematic review on peri‐operative lactate measurements to predict outcomes in patients undergoing liver resection
por: Connolly, Catherine, et al.
Publicado: (2020)

T cell exhaustion: from pathophysiological basics to tumor immunotherapy
por: Catakovic, Kemal, et al.
Publicado: (2017)

Primary tumour location affects survival after resection of colorectal liver metastases: A two-institutional cohort study with international validation, systematic meta-analysis and a clinical risk score
por: Gasser, Elisabeth, et al.
Publicado: (2019)

New method for real-time visualization and quantitative characterization of early colorectal cancer in endoscopy: a pilot study
por: Wagner, Andrej, et al.
Publicado: (2022)

Associations of Oxidative Stress and Postoperative Outcome in Liver Surgery with an Outlook to Future Potential Therapeutic Options
por: Senoner, Thomas, et al.
Publicado: (2019)

Impact of PD-L1 Scores and Changes on Clinical Outcome in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiotherapy
por: Huemer, Florian, et al.
Publicado: (2020)

The PEritoneal SUrface CAlculator (PESUCA): A new tool to quantify the resected peritoneal surface area after cytoreductive surgery
por: Schredl, Philipp, et al.
Publicado: (2020)

Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer
por: Deloria, Abigail J., et al.
Publicado: (2016)

Can We Efficiently Target HDAC in Cancer?
por: Kiesslich, Tobias, et al.
Publicado: (2022)

Absence of Stress Hyperglycemia Indicates the Most Severe Form of Blunt Liver Trauma
por: Kreutziger, Janett, et al.
Publicado: (2021)

NRF2: The key to tumor- and patient-dependent chemosensitivity in biliary tract cancer?
por: Kiesslich, Tobias, et al.
Publicado: (2019)

Aggressive local treatment for recurrent intrahepatic cholangiocarcinoma—Stereotactic radiofrequency ablation as a valuable addition to hepatic resection
por: Braunwarth, Eva, et al.
Publicado: (2022)

Non-operative management of blunt hepatic and splenic injuries–practical aspects and value of radiological scoring systems
por: Fodor, Margot, et al.
Publicado: (2018)

NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients
por: Prochazka, Katharina T, et al.
Publicado: (2016)

Early response evaluation during preoperative chemotherapy for colorectal liver metastases: Combined size and morphology‐based criteria predict pathological response and survival after resection
por: Primavesi, Florian, et al.
Publicado: (2019)

The prognostic value of Presepsin for postoperative complications following pancreatic resection: A prospective study
por: Gasteiger, Silvia, et al.
Publicado: (2020)

The green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells
por: Mayr, Christian, et al.
Publicado: (2015)

Hepatocellular carcinoma: Therapeutic advances in signaling, epigenetic and immune targets
por: Neureiter, Daniel, et al.
Publicado: (2019)

Sex differences in disease presentation, surgical and oncological outcome of liver resection for primary and metastatic liver tumors—A retrospective multicenter study
por: Braunwarth, Eva, et al.
Publicado: (2020)

Early Post-Operative Pancreatitis and Systemic Inflammatory Response Assessed by Serum Lipase and IL-6 Predict Pancreatic Fistula
por: Gasteiger, S., et al.
Publicado: (2020)

Surgical techniques and strategies for the treatment of primary liver tumours: hepatocellular and cholangiocellular carcinoma
por: Braunwarth, Eva, et al.
Publicado: (2018)

Validation of the revised 2018 AAST-OIS classification and the CT severity index for prediction of operative management and survival in patients with blunt spleen and liver injuries
por: Morell-Hofert, Dagmar, et al.
Publicado: (2020)

MicroRNAs Associated with the Efficacy of Photodynamic Therapy in Biliary Tract Cancer Cell Lines
por: Wagner, Andrej, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_53avcpujtt5tppp7ckevn77o30