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Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice

Obesity is a metabolic disorder that results from complex interactions between genetic predisposition and dietary factors. Interleukin-4 (IL-4), besides its role in immunity, has metabolic effects on insulin efficacy. We studied the effects of IL-4 on metabolic abnormalities in a mice model of obesi...

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Autores principales: Lin, Shih-Yi, Yang, Ching-Ping, Wang, Ya-Yu, Hsiao, Chiao-Wan, Chen, Wen-Ying, Liao, Su-Lan, Lo, Yu-Li, Chang, Yih-Hsin, Hong, Chen-Jee, Chen, Chun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352748/
https://www.ncbi.nlm.nih.gov/pubmed/32585823
http://dx.doi.org/10.3390/ijms21124451
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author Lin, Shih-Yi
Yang, Ching-Ping
Wang, Ya-Yu
Hsiao, Chiao-Wan
Chen, Wen-Ying
Liao, Su-Lan
Lo, Yu-Li
Chang, Yih-Hsin
Hong, Chen-Jee
Chen, Chun-Jung
author_facet Lin, Shih-Yi
Yang, Ching-Ping
Wang, Ya-Yu
Hsiao, Chiao-Wan
Chen, Wen-Ying
Liao, Su-Lan
Lo, Yu-Li
Chang, Yih-Hsin
Hong, Chen-Jee
Chen, Chun-Jung
author_sort Lin, Shih-Yi
collection PubMed
description Obesity is a metabolic disorder that results from complex interactions between genetic predisposition and dietary factors. Interleukin-4 (IL-4), besides its role in immunity, has metabolic effects on insulin efficacy. We studied the effects of IL-4 on metabolic abnormalities in a mice model of obesity involving leptin deficiency and leptin resistance. Leptin-deficient 145E and leptin-resistant high-fat diet (HFD) mice showed lower levels of circulating IL-4. 145E and HFD mice showed a number of abnormalities: Obesity, hyperglycemia, hyperinsulinemia, insulin resistance, dyslipidemia, liver injury, and adiposity with concurrent inflammation, decreases in Akt, signal transducer and activator of transcription 3 (STAT3), and STAT6 phosphorylation in the hypothalamus, liver, and epididymal fat. Independent of leptin-deficient obesity and dietary obesity, a course of 8-week IL-4 supplementation improved obesity and impairment in Akt, STAT3, and STAT6 signaling. Amelioration of cytokine expression, despite variable extents, was closely linked with the actions of IL-4. Additionally, the browning of white adipocytes by IL-4 was found in epididymal white adipose tissues and 3T3-L1 preadipocytes. Chronic exercise, weight management, and probiotics are recommended to overweight patients and IL-4 signaling is associated with clinical improvement. Thus, IL-4 could be a metabolic regulator and antiobesity candidate for the treatment of obesity and its complications.
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spelling pubmed-73527482020-07-15 Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice Lin, Shih-Yi Yang, Ching-Ping Wang, Ya-Yu Hsiao, Chiao-Wan Chen, Wen-Ying Liao, Su-Lan Lo, Yu-Li Chang, Yih-Hsin Hong, Chen-Jee Chen, Chun-Jung Int J Mol Sci Article Obesity is a metabolic disorder that results from complex interactions between genetic predisposition and dietary factors. Interleukin-4 (IL-4), besides its role in immunity, has metabolic effects on insulin efficacy. We studied the effects of IL-4 on metabolic abnormalities in a mice model of obesity involving leptin deficiency and leptin resistance. Leptin-deficient 145E and leptin-resistant high-fat diet (HFD) mice showed lower levels of circulating IL-4. 145E and HFD mice showed a number of abnormalities: Obesity, hyperglycemia, hyperinsulinemia, insulin resistance, dyslipidemia, liver injury, and adiposity with concurrent inflammation, decreases in Akt, signal transducer and activator of transcription 3 (STAT3), and STAT6 phosphorylation in the hypothalamus, liver, and epididymal fat. Independent of leptin-deficient obesity and dietary obesity, a course of 8-week IL-4 supplementation improved obesity and impairment in Akt, STAT3, and STAT6 signaling. Amelioration of cytokine expression, despite variable extents, was closely linked with the actions of IL-4. Additionally, the browning of white adipocytes by IL-4 was found in epididymal white adipose tissues and 3T3-L1 preadipocytes. Chronic exercise, weight management, and probiotics are recommended to overweight patients and IL-4 signaling is associated with clinical improvement. Thus, IL-4 could be a metabolic regulator and antiobesity candidate for the treatment of obesity and its complications. MDPI 2020-06-23 /pmc/articles/PMC7352748/ /pubmed/32585823 http://dx.doi.org/10.3390/ijms21124451 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Shih-Yi
Yang, Ching-Ping
Wang, Ya-Yu
Hsiao, Chiao-Wan
Chen, Wen-Ying
Liao, Su-Lan
Lo, Yu-Li
Chang, Yih-Hsin
Hong, Chen-Jee
Chen, Chun-Jung
Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice
title Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice
title_full Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice
title_fullStr Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice
title_full_unstemmed Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice
title_short Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice
title_sort interleukin-4 improves metabolic abnormalities in leptin-deficient and high-fat diet mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352748/
https://www.ncbi.nlm.nih.gov/pubmed/32585823
http://dx.doi.org/10.3390/ijms21124451
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