Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling

Colorectal cancer patients’ responses to neoadjuvant therapy undergo broad inter-individual variations. The aim of this systematic review is to identify a molecular signature that is predictive of colon cancer downstaging and/or downgrading after neoadjuvant therapy. Among the hundreds analysed in t...

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Autores principales: Izzotti, Alberto, Ceccaroli, Chiara, Geretto, Marta, Ruggieri, Filippo Grillo, Schenone, Sara, Di Maria, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352797/
https://www.ncbi.nlm.nih.gov/pubmed/32580435
http://dx.doi.org/10.3390/cancers12061652
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author Izzotti, Alberto
Ceccaroli, Chiara
Geretto, Marta
Ruggieri, Filippo Grillo
Schenone, Sara
Di Maria, Emilio
author_facet Izzotti, Alberto
Ceccaroli, Chiara
Geretto, Marta
Ruggieri, Filippo Grillo
Schenone, Sara
Di Maria, Emilio
author_sort Izzotti, Alberto
collection PubMed
description Colorectal cancer patients’ responses to neoadjuvant therapy undergo broad inter-individual variations. The aim of this systematic review is to identify a molecular signature that is predictive of colon cancer downstaging and/or downgrading after neoadjuvant therapy. Among the hundreds analysed in the available studies, only 19 messenger-RNAs (mRNAs) and six micro-RNAs (miRNAs) were differentially expressed in responders versus non-responders in two or more independent studies. Therefore, a mRNA/miRNA signature can be designed accordingly, with limitations caused by the retrospective nature of these studies, the heterogeneity in study designs and the downgrading/downstaging assessment criteria. This signature can be proposed to tailor neoadjuvant therapy regimens on an individual basis.
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spelling pubmed-73527972020-07-15 Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling Izzotti, Alberto Ceccaroli, Chiara Geretto, Marta Ruggieri, Filippo Grillo Schenone, Sara Di Maria, Emilio Cancers (Basel) Review Colorectal cancer patients’ responses to neoadjuvant therapy undergo broad inter-individual variations. The aim of this systematic review is to identify a molecular signature that is predictive of colon cancer downstaging and/or downgrading after neoadjuvant therapy. Among the hundreds analysed in the available studies, only 19 messenger-RNAs (mRNAs) and six micro-RNAs (miRNAs) were differentially expressed in responders versus non-responders in two or more independent studies. Therefore, a mRNA/miRNA signature can be designed accordingly, with limitations caused by the retrospective nature of these studies, the heterogeneity in study designs and the downgrading/downstaging assessment criteria. This signature can be proposed to tailor neoadjuvant therapy regimens on an individual basis. MDPI 2020-06-22 /pmc/articles/PMC7352797/ /pubmed/32580435 http://dx.doi.org/10.3390/cancers12061652 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Izzotti, Alberto
Ceccaroli, Chiara
Geretto, Marta
Ruggieri, Filippo Grillo
Schenone, Sara
Di Maria, Emilio
Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling
title Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling
title_full Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling
title_fullStr Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling
title_full_unstemmed Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling
title_short Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling
title_sort predicting response to neoadjuvant therapy in colorectal cancer patients the role of messenger-and micro-rna profiling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352797/
https://www.ncbi.nlm.nih.gov/pubmed/32580435
http://dx.doi.org/10.3390/cancers12061652
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