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A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

The diagnosis of adenocarcinomas located in the pancreas head, i.e., distal cholangiocarcinoma (dCCA) and pancreatic ductal adenocarcinoma (PDAC), constitutes a clinical challenge because they share many symptoms, are not easily distinguishable using imaging techniques and accurate biomarkers are no...

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Autores principales: Macias, Rocio I.R., Muñoz-Bellvís, Luis, Sánchez-Martín, Anabel, Arretxe, Enara, Martínez-Arranz, Ibon, Lapitz, Ainhoa, Gutiérrez, M. Laura, La Casta, Adelaida, Alonso, Cristina, González, Luis M., Avila, Matias A., Martinez-Chantar, Maria L., Castro, Rui E., Bujanda, Luis, Banales, Jesus M., Marin, Jose J.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352809/
https://www.ncbi.nlm.nih.gov/pubmed/32486461
http://dx.doi.org/10.3390/cancers12061433
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author Macias, Rocio I.R.
Muñoz-Bellvís, Luis
Sánchez-Martín, Anabel
Arretxe, Enara
Martínez-Arranz, Ibon
Lapitz, Ainhoa
Gutiérrez, M. Laura
La Casta, Adelaida
Alonso, Cristina
González, Luis M.
Avila, Matias A.
Martinez-Chantar, Maria L.
Castro, Rui E.
Bujanda, Luis
Banales, Jesus M.
Marin, Jose J.G.
author_facet Macias, Rocio I.R.
Muñoz-Bellvís, Luis
Sánchez-Martín, Anabel
Arretxe, Enara
Martínez-Arranz, Ibon
Lapitz, Ainhoa
Gutiérrez, M. Laura
La Casta, Adelaida
Alonso, Cristina
González, Luis M.
Avila, Matias A.
Martinez-Chantar, Maria L.
Castro, Rui E.
Bujanda, Luis
Banales, Jesus M.
Marin, Jose J.G.
author_sort Macias, Rocio I.R.
collection PubMed
description The diagnosis of adenocarcinomas located in the pancreas head, i.e., distal cholangiocarcinoma (dCCA) and pancreatic ductal adenocarcinoma (PDAC), constitutes a clinical challenge because they share many symptoms, are not easily distinguishable using imaging techniques and accurate biomarkers are not available. Searching for biomarkers with potential usefulness in the differential diagnosis of these tumors, we have determined serum metabolomic profiles in healthy controls and patients with dCCA, PDAC or benign pancreatic diseases (BPD). Ultra-high-performance liquid chromatography coupled to mass spectrometry (UHPLC-MS) analysis was performed in serum samples from dCCA (n = 34), PDAC (n = 38), BPD (n = 42) and control (n = 25) individuals, divided into discovery and validation cohorts. This approach permitted 484 metabolites to be determined, mainly lipids and amino acids. The analysis of the results led to the proposal of a logistic regression model able to discriminate patients with dCCA and PDAC (AUC value of 0.888) based on the combination of serum levels of nine metabolites (acylcarnitine AC(16:0), ceramide Cer(d18:1/24:0), phosphatidylcholines PC(20:0/0:0) and PC(O-16:0/20:3), lysophosphatidylcholines PC(20:0/0:0) and PC(0:0/20:0), lysophosphatidylethanolamine PE(P-18:2/0:0), and sphingomyelins SM(d18:2/22:0) and SM(d18:2/23:0)) and CA 19-9. In conclusion, we propose a novel specific panel of serum metabolites that can help in the differential diagnosis of dCCA and PDAC. Further validation of their clinical usefulness in prospective studies is required.
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spelling pubmed-73528092020-07-15 A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma Macias, Rocio I.R. Muñoz-Bellvís, Luis Sánchez-Martín, Anabel Arretxe, Enara Martínez-Arranz, Ibon Lapitz, Ainhoa Gutiérrez, M. Laura La Casta, Adelaida Alonso, Cristina González, Luis M. Avila, Matias A. Martinez-Chantar, Maria L. Castro, Rui E. Bujanda, Luis Banales, Jesus M. Marin, Jose J.G. Cancers (Basel) Article The diagnosis of adenocarcinomas located in the pancreas head, i.e., distal cholangiocarcinoma (dCCA) and pancreatic ductal adenocarcinoma (PDAC), constitutes a clinical challenge because they share many symptoms, are not easily distinguishable using imaging techniques and accurate biomarkers are not available. Searching for biomarkers with potential usefulness in the differential diagnosis of these tumors, we have determined serum metabolomic profiles in healthy controls and patients with dCCA, PDAC or benign pancreatic diseases (BPD). Ultra-high-performance liquid chromatography coupled to mass spectrometry (UHPLC-MS) analysis was performed in serum samples from dCCA (n = 34), PDAC (n = 38), BPD (n = 42) and control (n = 25) individuals, divided into discovery and validation cohorts. This approach permitted 484 metabolites to be determined, mainly lipids and amino acids. The analysis of the results led to the proposal of a logistic regression model able to discriminate patients with dCCA and PDAC (AUC value of 0.888) based on the combination of serum levels of nine metabolites (acylcarnitine AC(16:0), ceramide Cer(d18:1/24:0), phosphatidylcholines PC(20:0/0:0) and PC(O-16:0/20:3), lysophosphatidylcholines PC(20:0/0:0) and PC(0:0/20:0), lysophosphatidylethanolamine PE(P-18:2/0:0), and sphingomyelins SM(d18:2/22:0) and SM(d18:2/23:0)) and CA 19-9. In conclusion, we propose a novel specific panel of serum metabolites that can help in the differential diagnosis of dCCA and PDAC. Further validation of their clinical usefulness in prospective studies is required. MDPI 2020-05-31 /pmc/articles/PMC7352809/ /pubmed/32486461 http://dx.doi.org/10.3390/cancers12061433 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Macias, Rocio I.R.
Muñoz-Bellvís, Luis
Sánchez-Martín, Anabel
Arretxe, Enara
Martínez-Arranz, Ibon
Lapitz, Ainhoa
Gutiérrez, M. Laura
La Casta, Adelaida
Alonso, Cristina
González, Luis M.
Avila, Matias A.
Martinez-Chantar, Maria L.
Castro, Rui E.
Bujanda, Luis
Banales, Jesus M.
Marin, Jose J.G.
A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
title A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
title_full A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
title_fullStr A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
title_full_unstemmed A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
title_short A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma
title_sort novel serum metabolomic profile for the differential diagnosis of distal cholangiocarcinoma and pancreatic ductal adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352809/
https://www.ncbi.nlm.nih.gov/pubmed/32486461
http://dx.doi.org/10.3390/cancers12061433
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