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The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis
Background: Elevated fasting remnant cholesterol (REM-C) levels have been associated with an increased cardiovascular risk in patients with metabolic syndrome (Mets) and Non-Alcoholic Fatty Liver Disease (NAFLD). We aimed to estimate the effect of different diets on REM-C levels in patients with Met...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352824/ https://www.ncbi.nlm.nih.gov/pubmed/32512752 http://dx.doi.org/10.3390/nu12061674 |
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author | Campanella, Angelo Iacovazzi, Palma A. Misciagna, Giovanni Bonfiglio, Caterina Mirizzi, Antonella Franco, Isabella Bianco, Antonella Sorino, Paolo Caruso, Maria G. Cisternino, Anna M. Buongiorno, Claudia Liuzzi, Rosalba Osella, Alberto R. |
author_facet | Campanella, Angelo Iacovazzi, Palma A. Misciagna, Giovanni Bonfiglio, Caterina Mirizzi, Antonella Franco, Isabella Bianco, Antonella Sorino, Paolo Caruso, Maria G. Cisternino, Anna M. Buongiorno, Claudia Liuzzi, Rosalba Osella, Alberto R. |
author_sort | Campanella, Angelo |
collection | PubMed |
description | Background: Elevated fasting remnant cholesterol (REM-C) levels have been associated with an increased cardiovascular risk in patients with metabolic syndrome (Mets) and Non-Alcoholic Fatty Liver Disease (NAFLD). We aimed to estimate the effect of different diets on REM-C levels in patients with MetS, as well as the association between NAFLD and REM-C. Methods: This is a secondary analysis of the MEDIDIET study, a parallel-arm Randomized Clinical Trial (RCT). We examined 237 people with MetS who underwent Liver Ultrasound (LUS) to assess the NAFLD score at baseline, 3-, and 6-months follow-up. Subjects were randomly assigned to the Mediterranean diet (MD), Low Glycemic Index diet (LGID), or Low Glycemic Index Mediterranean diet (LGIMD). REM-C was calculated as [total cholesterol–low density lipoprotein cholesterol (LDL-C)–high density lipoprotein cholesterol (HDL-C)]. Results: REM-C levels were higher in subjects with moderate or severe NAFLD than in mild or absent ones. All diets had a direct effect in lowering the levels of REM-C after 3 and 6 months of intervention. In adherents subjects, this effect was stronger among LGIMD as compared to the control group. There was also a significant increase in REM-C levels among Severe NAFLD subjects at 3 months and a decrease at 6 months. Conclusions: fasting REM-C level is independently associated with the grade of severity of NAFLD. LGIMD adherence directly reduced the fasting REM-C in patients with MetS. |
format | Online Article Text |
id | pubmed-7352824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73528242020-07-15 The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis Campanella, Angelo Iacovazzi, Palma A. Misciagna, Giovanni Bonfiglio, Caterina Mirizzi, Antonella Franco, Isabella Bianco, Antonella Sorino, Paolo Caruso, Maria G. Cisternino, Anna M. Buongiorno, Claudia Liuzzi, Rosalba Osella, Alberto R. Nutrients Article Background: Elevated fasting remnant cholesterol (REM-C) levels have been associated with an increased cardiovascular risk in patients with metabolic syndrome (Mets) and Non-Alcoholic Fatty Liver Disease (NAFLD). We aimed to estimate the effect of different diets on REM-C levels in patients with MetS, as well as the association between NAFLD and REM-C. Methods: This is a secondary analysis of the MEDIDIET study, a parallel-arm Randomized Clinical Trial (RCT). We examined 237 people with MetS who underwent Liver Ultrasound (LUS) to assess the NAFLD score at baseline, 3-, and 6-months follow-up. Subjects were randomly assigned to the Mediterranean diet (MD), Low Glycemic Index diet (LGID), or Low Glycemic Index Mediterranean diet (LGIMD). REM-C was calculated as [total cholesterol–low density lipoprotein cholesterol (LDL-C)–high density lipoprotein cholesterol (HDL-C)]. Results: REM-C levels were higher in subjects with moderate or severe NAFLD than in mild or absent ones. All diets had a direct effect in lowering the levels of REM-C after 3 and 6 months of intervention. In adherents subjects, this effect was stronger among LGIMD as compared to the control group. There was also a significant increase in REM-C levels among Severe NAFLD subjects at 3 months and a decrease at 6 months. Conclusions: fasting REM-C level is independently associated with the grade of severity of NAFLD. LGIMD adherence directly reduced the fasting REM-C in patients with MetS. MDPI 2020-06-04 /pmc/articles/PMC7352824/ /pubmed/32512752 http://dx.doi.org/10.3390/nu12061674 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Campanella, Angelo Iacovazzi, Palma A. Misciagna, Giovanni Bonfiglio, Caterina Mirizzi, Antonella Franco, Isabella Bianco, Antonella Sorino, Paolo Caruso, Maria G. Cisternino, Anna M. Buongiorno, Claudia Liuzzi, Rosalba Osella, Alberto R. The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis |
title | The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis |
title_full | The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis |
title_fullStr | The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis |
title_full_unstemmed | The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis |
title_short | The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis |
title_sort | effect of three mediterranean diets on remnant cholesterol and non-alcoholic fatty liver disease: a secondary analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352824/ https://www.ncbi.nlm.nih.gov/pubmed/32512752 http://dx.doi.org/10.3390/nu12061674 |
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