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Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies

Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves...

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Autores principales: Szabados, Tamara, Gömöri, Kamilla, Pálvölgyi, Laura, Görbe, Anikó, Baczkó, István, Helyes, Zsuzsanna, Jancsó, Gábor, Ferdinandy, Péter, Bencsik, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352834/
https://www.ncbi.nlm.nih.gov/pubmed/32586044
http://dx.doi.org/10.3390/ijms21124472
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author Szabados, Tamara
Gömöri, Kamilla
Pálvölgyi, Laura
Görbe, Anikó
Baczkó, István
Helyes, Zsuzsanna
Jancsó, Gábor
Ferdinandy, Péter
Bencsik, Péter
author_facet Szabados, Tamara
Gömöri, Kamilla
Pálvölgyi, Laura
Görbe, Anikó
Baczkó, István
Helyes, Zsuzsanna
Jancsó, Gábor
Ferdinandy, Péter
Bencsik, Péter
author_sort Szabados, Tamara
collection PubMed
description Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases.
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spelling pubmed-73528342020-07-15 Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies Szabados, Tamara Gömöri, Kamilla Pálvölgyi, Laura Görbe, Anikó Baczkó, István Helyes, Zsuzsanna Jancsó, Gábor Ferdinandy, Péter Bencsik, Péter Int J Mol Sci Review Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases. MDPI 2020-06-23 /pmc/articles/PMC7352834/ /pubmed/32586044 http://dx.doi.org/10.3390/ijms21124472 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szabados, Tamara
Gömöri, Kamilla
Pálvölgyi, Laura
Görbe, Anikó
Baczkó, István
Helyes, Zsuzsanna
Jancsó, Gábor
Ferdinandy, Péter
Bencsik, Péter
Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
title Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
title_full Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
title_fullStr Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
title_full_unstemmed Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
title_short Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
title_sort capsaicin-sensitive sensory nerves and the trpv1 ion channel in cardiac physiology and pathologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352834/
https://www.ncbi.nlm.nih.gov/pubmed/32586044
http://dx.doi.org/10.3390/ijms21124472
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