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Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352834/ https://www.ncbi.nlm.nih.gov/pubmed/32586044 http://dx.doi.org/10.3390/ijms21124472 |
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author | Szabados, Tamara Gömöri, Kamilla Pálvölgyi, Laura Görbe, Anikó Baczkó, István Helyes, Zsuzsanna Jancsó, Gábor Ferdinandy, Péter Bencsik, Péter |
author_facet | Szabados, Tamara Gömöri, Kamilla Pálvölgyi, Laura Görbe, Anikó Baczkó, István Helyes, Zsuzsanna Jancsó, Gábor Ferdinandy, Péter Bencsik, Péter |
author_sort | Szabados, Tamara |
collection | PubMed |
description | Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases. |
format | Online Article Text |
id | pubmed-7352834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73528342020-07-15 Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies Szabados, Tamara Gömöri, Kamilla Pálvölgyi, Laura Görbe, Anikó Baczkó, István Helyes, Zsuzsanna Jancsó, Gábor Ferdinandy, Péter Bencsik, Péter Int J Mol Sci Review Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases. MDPI 2020-06-23 /pmc/articles/PMC7352834/ /pubmed/32586044 http://dx.doi.org/10.3390/ijms21124472 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szabados, Tamara Gömöri, Kamilla Pálvölgyi, Laura Görbe, Anikó Baczkó, István Helyes, Zsuzsanna Jancsó, Gábor Ferdinandy, Péter Bencsik, Péter Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
title | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
title_full | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
title_fullStr | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
title_full_unstemmed | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
title_short | Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies |
title_sort | capsaicin-sensitive sensory nerves and the trpv1 ion channel in cardiac physiology and pathologies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352834/ https://www.ncbi.nlm.nih.gov/pubmed/32586044 http://dx.doi.org/10.3390/ijms21124472 |
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