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Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352836/ https://www.ncbi.nlm.nih.gov/pubmed/32580508 http://dx.doi.org/10.3390/ijms21124444 |
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author | Matrone, Carmela Petrillo, Federica Nasso, Rosarita Ferretti, Gabriella |
author_facet | Matrone, Carmela Petrillo, Federica Nasso, Rosarita Ferretti, Gabriella |
author_sort | Matrone, Carmela |
collection | PubMed |
description | Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. This review highlights and summarizes the most relevant recent findings pertinent to the role that Fyn exerts in the brain, emphasizing aspects related to neurodevelopment and synaptic plasticity. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. We will primarily focus on Fyn-mediated signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer’s disease. |
format | Online Article Text |
id | pubmed-7352836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73528362020-07-15 Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions Matrone, Carmela Petrillo, Federica Nasso, Rosarita Ferretti, Gabriella Int J Mol Sci Review Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. This review highlights and summarizes the most relevant recent findings pertinent to the role that Fyn exerts in the brain, emphasizing aspects related to neurodevelopment and synaptic plasticity. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. We will primarily focus on Fyn-mediated signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer’s disease. MDPI 2020-06-22 /pmc/articles/PMC7352836/ /pubmed/32580508 http://dx.doi.org/10.3390/ijms21124444 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Matrone, Carmela Petrillo, Federica Nasso, Rosarita Ferretti, Gabriella Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions |
title | Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions |
title_full | Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions |
title_fullStr | Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions |
title_full_unstemmed | Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions |
title_short | Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions |
title_sort | fyn tyrosine kinase as harmonizing factor in neuronal functions and dysfunctions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352836/ https://www.ncbi.nlm.nih.gov/pubmed/32580508 http://dx.doi.org/10.3390/ijms21124444 |
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