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Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions

Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years a...

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Detalles Bibliográficos
Autores principales: Matrone, Carmela, Petrillo, Federica, Nasso, Rosarita, Ferretti, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352836/
https://www.ncbi.nlm.nih.gov/pubmed/32580508
http://dx.doi.org/10.3390/ijms21124444
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author Matrone, Carmela
Petrillo, Federica
Nasso, Rosarita
Ferretti, Gabriella
author_facet Matrone, Carmela
Petrillo, Federica
Nasso, Rosarita
Ferretti, Gabriella
author_sort Matrone, Carmela
collection PubMed
description Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. This review highlights and summarizes the most relevant recent findings pertinent to the role that Fyn exerts in the brain, emphasizing aspects related to neurodevelopment and synaptic plasticity. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. We will primarily focus on Fyn-mediated signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer’s disease.
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spelling pubmed-73528362020-07-15 Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions Matrone, Carmela Petrillo, Federica Nasso, Rosarita Ferretti, Gabriella Int J Mol Sci Review Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. This review highlights and summarizes the most relevant recent findings pertinent to the role that Fyn exerts in the brain, emphasizing aspects related to neurodevelopment and synaptic plasticity. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. We will primarily focus on Fyn-mediated signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer’s disease. MDPI 2020-06-22 /pmc/articles/PMC7352836/ /pubmed/32580508 http://dx.doi.org/10.3390/ijms21124444 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matrone, Carmela
Petrillo, Federica
Nasso, Rosarita
Ferretti, Gabriella
Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
title Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
title_full Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
title_fullStr Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
title_full_unstemmed Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
title_short Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
title_sort fyn tyrosine kinase as harmonizing factor in neuronal functions and dysfunctions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352836/
https://www.ncbi.nlm.nih.gov/pubmed/32580508
http://dx.doi.org/10.3390/ijms21124444
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