Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

Mixed lineage leukemia (MLL) (KMT2A) rearrangements (KMT2Ar) play a crucial role in leukemogenesis. Dependent on age, major differences exist regarding disease frequency, main fusion partners and prognosis. In infants, up to 80% of acute lymphoid leukemia (ALL) bear a MLL translocation and half of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Secker, Kathy-Ann, Bruns, Lukas, Keppeler, Hildegard, Jeong, Johan, Hentrich, Thomas, Schulze-Hentrich, Julia M., Mankel, Barbara, Fend, Falko, Schneidawind, Dominik, Schneidawind, Corina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352867/
https://www.ncbi.nlm.nih.gov/pubmed/32517300
http://dx.doi.org/10.3390/cancers12061487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352867/
https://www.ncbi.nlm.nih.gov/pubmed/32517300
http://dx.doi.org/10.3390/cancers12061487

Ejemplares similares