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Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

Mixed lineage leukemia (MLL) (KMT2A) rearrangements (KMT2Ar) play a crucial role in leukemogenesis. Dependent on age, major differences exist regarding disease frequency, main fusion partners and prognosis. In infants, up to 80% of acute lymphoid leukemia (ALL) bear a MLL translocation and half of t...

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Detalles Bibliográficos
Autores principales:	Secker, Kathy-Ann, Bruns, Lukas, Keppeler, Hildegard, Jeong, Johan, Hentrich, Thomas, Schulze-Hentrich, Julia M., Mankel, Barbara, Fend, Falko, Schneidawind, Dominik, Schneidawind, Corina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352867/ https://www.ncbi.nlm.nih.gov/pubmed/32517300 http://dx.doi.org/10.3390/cancers12061487

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